新生儿重症监护病房患儿多重耐药肺炎克雷伯菌耐药情况及危险因素分析OACSTPCD

Objective:To explore rational prevention and treatment strategies by investigating the clinical features and drug resistance of Klebsiella pneumoniae in patients from neonatal intensive care unit(NICU)of Qian Xi Nan People's Hospital.Methods:Clinical data of 103 patients with K.pneumoniae in NICU of the hospital from 2020 to 2021 were retrospectively analyzed.SPSS 23.0 statistical software was used to analyze the difference between 57 cases of multi-drug resistance K.pneumoniae(MDR-Kpn)and 46 cases of non-MDR-K.pneumoniae infection.Moreover,the risk factors related to MDR-Kpn were investigated.Results:The risk factors related to MDR-Kpn included premature delivery,exposure to ≥ 2 kinds of antibiotics,low birth weight,prolonged length of stay,premature rupture of membranes,explosure duration of antibiotics,high nutritional risk score,and high Score for Neonatal Acute Physiology-Ⅱand Perinatal Extension(SNAPPE-Ⅱ).Among them,premature delivery(OR=0.255,95％CI 0.074 to 0.876,P=0.023),premature rupture of membranes(OR=0.279,95％CI 0.095 to 0.817,P=0.020),high nutritional risk score(OR=0.165,95％CI 0.030 to 0.906,P=0.038),and exposure to ≥ 2 kinds of antibiotics(OR=0.242,95％CI 0.063 to 0.936,P=0.040)were independent risk factors related to MDR-Kpn.Conclusion:NICU shall pay more attention to the administration of antibiotics under an increasingly high incidence of K.pneumoniae.Much attention should be paid to these premature infants with premature rupture of membranes and malnutrition,so as to reduce the occurrence of MDR-Kpn in clinical practice.