基于网络药理学探讨赖氨肌醇维生素B12口服液治疗小儿厌食症的作用机制OACSTPCD

Objective:To explore the mechanism of lysine,inosite and vitamin B12 oral solution in the treatment of anorexia in children based on network pharmacology.Methods:By referring to drug instructions,the components of lysine,inosite and vitamin B12 oral solution were excavated,the correlation targets of components were predicted through Swiss Target Prediction website,and the intersection mapping was made with the targets of anorexia,so as to obtain the therapeutic targets of anorexia in children.Protein-protein interaction(PPI)was used to screen core targets and molecular docking verification was carried out.Based on common targets,functional annotation bioinformatics chip was used for analysis,and the key pathway of lysine,inosite and vitamin B12 oral solution in the treatment of anorexia in children was obtained.Results:Lysine hydrochloride,inositol and vitamin B12 were the main components in lysine,inosite and vitamin B12 oral solution.A total of 40 target genes were predicted,among which 13 target genes were closely related to anorexism,mainly including glutamate receptor signaling pathway and neuroactive ligand receptor interaction.Conclusion:Lysine,inosite and vitamin B12 oral solution may play a similar role to glutamate,and improve anorexia in children by activating glutamate receptors in the postsynaptic membrane,which reflects the synergistic effect of multiple components and multiple targets.