IRES介导的非帽依赖翻译调控研究进展OACSTPCD
Review on IRES-mediated cap-independent translation regulation
内部核糖体进入位点(Internal ribosome entry site,IRES)是一种存在于RNA内部的特殊功能元件,其可在不依赖5'端帽子结构的情况下直接招募核糖体启动蛋白翻译,已被发现与多种细胞过程密切相关.近来,越来越多的证据表明IRES在环形RNA翻译调控中扮演着极其重要的角色,由此IRES引起人们的极大关注.本文针对目前真核细胞中IRES介导的翻译调控机制进行了综述,并对IRES元件相关生物信息学工具进行了总结.
Internal ribosome entry site(IRES)is a special functional element in RNA,which can directly recruit ribosome to initiate protein translation independently of the 5'end cap structure.It has been found to be closely related to a variety of cell processes.Recently,IRES have attracted a lot of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation.This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells,and summarizes the bioinformatics tools related to IRES elements.
轩依然;赵健;宋晓峰
南京航空航天大学 自动化学院,南京 211106
基础医学
内部核糖体进入位点非帽依赖翻译反式作用因子G-四链体上游开放阅读框
Internal ribosome entry siteCap-independent translationITAFG-quadruplexuORF
《生物信息学》 2024 (001)
1-10 / 10
国家自然科学基金项目(No.62003165,62273175,61973155);江苏省重点研发计划项目(No.BE2022843);中国博士后科学基金项目(No.2019M661817).
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