儿童心肌炎病因学及发病机制进展OA北大核心CSTPCD

Myocarditis is a common disease in children.Myocarditis is a disease characterized by localized or diffuse inflammatory lesions in the myocardial tissue,primarily manifested by myocardial cell necrosis and inflammatory cell infiltration in the interstitium.The etiology of myocarditis includes infectious and non-infectious causes.Viral infections have been proven to be the most common infectious cause,while autoimmune factors and drugs play a major role in non-infectious causes.The pathogenesis of myocarditis involves direct and secondary damage to myocardial cells,immunological mechanisms,abnormal gene signaling pathways,miRNA,genetic susceptibility,and other factors.ln recent years,there has been considerable attention given to myocarditis due to the global pandemic of the novel coronavirus and the widespread application its vaccine.This article elaborates on the current research status and progress of the etiology and pathogenesis of myocarditis.