基于功能连接分析对基底节区卒中患者的偏侧化研究OA北大核心CSTPCD

Objective:To explore the altered static and dynamic functional connectivity of the brain in patients with left-sided basal ganglia stroke(L-BGS)versus right-sided basal ganglia stroke(R-BGS)and to further explore the mechanisms of stroke lateralisation.Materials and Methods:Twenty-three L-BGS patients,18 R-BGS patients and 20 healthy controls(HCs)were analysed,and resting-state functional MRI(rs-fMRI)was performed on each of the three groups of subjects.Based on rs-fMRI and sliding window techniques,static functional connectivity analysis and dynamic functional connectivity analysis were performed on the two groups of patients and HCs,respectively.Results:In static brain network connectivity analysis,L-BGS patients had more extensive increased and decreased intra-network connectivity compared to HCs(P<0.001,cluster level FWE correction);R-BGS patients had more extensive impaired inter-network connectivity compared to HCs(P<0.016 7,FDR correction).In dynamic connectivity analyses,L-BGS showed more positive reorganisation of network connectivity compared to HCs(P<0.05,FDR corrected).Conclusions:The present study confirms that within 1 month of basal ganglia stroke onset,L-BGS patients show more positive compensatory changes in static and dynamic brain network connectivity.