华西口腔医学杂志2024，Vol.42Issue(2)：181-191,11.DOI:10.7518/hxkq.2024.2023285
基于网络药理学和分子对接技术探讨人参对牙周炎的潜在治疗机制
Potential mechanism of ginseng in the treatment of periodontitis based on network pharmacology and molecular docking
摘要
Abstract
Objective To explore the mechanism of ginseng in the treatment of periodontitis based on network phar-macology and molecular docking technology.Methods Potential targets of ginseng and periodontitis were obtained through various databases.The intersection targets of ginseng and periodontitis were obtained by using VENNY,the pro-tein-protein interaction network relationship diagram was formed on the STRING platform,the core target diagram was formed by Cytoscape software,and the ginseng-active ingredient-target network diagram was constructed.The selected targets were screened for gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway en-richment analysis.The core targets of ginseng's active in-gredients in treating periodontitis were analyzed by mo-lecular docking technique.Results The 22 ginseng's active ingredients,591 potential targets of ginseng's ac-tive ingredients,2 249 periodontitis gene targets,and 145 ginseng-periodontitis intersection targets were analyzed.Ginseng had strong binding activity on core targets such as vas-cular endothelial growth factor A and epidermal growth factor receptor,as well as hypoxia induced-factor 1(HIF-1)sig-naling pathway and phosphatidylinositol 3-kinase-protein kinase B(PI3K-Akt)signaling pathway.Conclusion Gin-seng and its active components can regulate several signaling pathways such as HIF-1 and PI3K-Akt,thereby indicating that ginseng may play a role in treating periodontitis through multiple pathways.关键词
人参/牙周炎/网络药理学/分子对接/作用机制Key words
ginseng/periodontitis/network pharmacology/molecular docking/mechanism分类
医药卫生引用本文复制引用
孙金梦,张颖,郑泽君,丁晓玲,孙敏敏,丁刚..基于网络药理学和分子对接技术探讨人参对牙周炎的潜在治疗机制[J].华西口腔医学杂志,2024,42(2):181-191,11.基金项目
The National Natural Science Foundation of China(81570945) （81570945）
Natural Science Foundation of Shandong Province(ZR2022QH273,ZR2021MH051) （ZR2022QH273,ZR2021MH051）
Postgraduate Education Quality Improvement Plan of Shandong Province(SDYAL21150) （SDYAL21150）
Graduate Student Research Grant from Shandong Second Medical University(2023YJSCX008) 国家自然科学基金(81570945) （2023YJSCX008）
山东省自然科学基金(ZR2022QH273,ZR2021MH051) （ZR2022QH273,ZR2021MH051）
山东省研究生教育质量提升计划(SDYAL21150) （SDYAL21150）
山东第二医科大学研究生科研创新基金(2023YJSCX008) （2023YJSCX008）
