四川大学学报（医学版）2024，Vol.55Issue(2)：263-272,10.DOI:10.12182/20240360301
circRNA-miRNA网络调控骨重塑的研究进展
Research Progress in the Regulatory Role of circRNA-miRNA Network in Bone Remodeling
摘要
Abstract
The dynamic balance between bone formation and bone resorption is a critical process of bone remodeling.The imbalance of bone formation and bone resorption is closely associated with the occurrence and development of various bone-related diseases.Under both physiological and pathological conditions,non-coding RNAs(ncRNAs)play a crucial regulatory role in protein expression through either inhibiting mRNAs translation or promoting mRNAs degradation.Circular RNAs(circRNAs)are a type of non-linear ncRNAs that can resist the degradation of RNA exonucleases.There is accumulating evidence suggesting that circRNAs and microRNAs(miRNAs)serve as critical regulators of bone remodeling through their direct or indirect regulation of the expression of osteogenesis-related genes.Additionally,recent studies have revealed the involvement of the circRNAs-miRNAs regulatory network in the process by which mesenchymal stem cells(MSCs)differentiate towards the osteoblasts(OB)lineage and the process by which bone marrow-derived macrophages(BMDM)differentiate towards osteoclasts(OC).The circRNA-miRNA network plays an important regulatory role in the osteoblastic-osteoclastic balance of bone remodeling.Therefore,a thorough understanding of the circRNA-miRNA regulatory mechanisms will contribute to a better understanding of the regulatory mechanisms of the balance between osteoblastic and osteoclastic activities in the process of bone remodeling and the diagnosis and treatment of related diseases.Herein,we reviewed the functions of circRNA and microRNA.We also reviewed their roles in and the mechanisms of the circRNA-miRNA regulatory network in the process of bone remodeling.This review provides references and ideas for further research on the regulation of bone remodeling and the prevention and treatment of bone-related diseases.关键词
环状RNA/微小RNA/成骨分化/破骨分化/骨重塑/综述Key words
Circular RNA/microRNA/Osteogenic differentiation/Osteoclastic differentiation/Bone remodeling/Review引用本文复制引用
兰元辰,余丽媛,胡芝爱,邹淑娟..circRNA-miRNA网络调控骨重塑的研究进展[J].四川大学学报（医学版）,2024,55(2):263-272,10.基金项目
国家自然科学基金(No.82271017、No.82001108)、中国博士后科学基金(No.2020M683331)、四川大学华西口腔医学院(华西口腔医院)科研经费资助项目(No.RCDWJS2022-4)和四川省科技厅应用基础研究项目(No.2022NSFSC0595)资助 （No.82271017、No.82001108）
