颈动脉内中膜厚度与亚临床左心室收缩功能的关系OA北大核心CSTPCD

Objective:To explore the relationship between carotid intima-media thickness(cIMT)and subclinical left ventricular function in population of Danyang community.Methods:The study subjects were recruited in 2021 from the Station Community of Danyang City,Jiangsu Province.cIMT was measured and analyzed by GE Vivid E90 ultrasound instrument.Two-dimensional(2D)speckle tracking technology was used to collect left ventricular global longitudinal strain(LVGLS)of the left ventricle as an indicator for assessing subclinical systolic function.The e'and E/e'ratio were obtained from mitral valve blood flow spectra and tissue Doppler imaging,serving as indicators for evaluating subclinical diastolic function.Results:A total of 561 participants with an average age of(58.2±11.7)years were enrolled,among whom 339(60.4%)were females.Using tertiles of cIMT as a categorical variable,in univariate analysis,LVGLS,E/A ratio,and e'decreased as cIMT tertiles increased,while the E/e'ratio increased(all Ptrend≤0.002),except for left ventricular ejection fraction.However,after further multivariate adjustment,only LVGLS continued to decrease with increasing cIMT tertiles(P<0.05).Continuous variable analysis after natural logarithm transformation of cIMT yielded results similar to categorical variable analysis,with only LVGLS showing a significant negative correlation with cIMT(r=-0.087,P=0.041),and similar findings were observed in regression analysis(β=-1.12,P=0.041).Conclusion:In the Danyang community population in Jiangsu,increased cIMT is independently correlated with decreased GLS.