国际眼科杂志2024，Vol.24Issue(4)：601-606,6.DOI:10.3980/j.issn.1672-5123.2024.4.20
重型β地中海贫血眼部变化的研究现状
Research status of ocular changes in beta-thalassemia major
摘要
Abstract
Beta-thalassemia major(β-TM)is an inherited disease caused by a defect in the synthesis of globin.The disease requires long-term blood transfusion and iron chelator treatment,which can cause various secondary changes in the body and eye tissues.Compared with normal peers,β-TM patients will show changes in the eye such as steeper corneal curvature,shallower anterior chamber,increased lens thickness,shorter axial length,and reduced tear secretion.At the same time,nutritional deficiencies and the use of iron chelator drugs will increase the risk of complicated cataract and retinal degeneration,thus affecting the quality of life of β-TM patients.This article combines relevant domestic and foreign literatures to explore and review the changes in the eye of β-TM patients,with a view to providing valuable insights for clinical practice.关键词
重型β地中海贫血/眼部变化/输血/铁螯合剂/氧化应激Key words
beta-thalassemia major/ocular changes/transfusion/iron chelator/oxidative stress引用本文复制引用
魏永灿,陈丹娜,李雯文,仝娅妮,赵桂玲..重型β地中海贫血眼部变化的研究现状[J].国际眼科杂志,2024,24(4):601-606,6.基金项目
广东医科大学青年科研培育基金项目(No.GDMUQ2022033) Youth Research and Cultivation Fund Project of Guangdong Medical University(No.GDMUQ2022033) （No.GDMUQ2022033）
