炙黄芪-水蛭联合阿加曲班注射液治疗气虚血瘀型急性脑梗死的疗效观察OACSTPCD
Effect of baked Astragalus Hirudo combined with Agattriban Injection on acute cerebral infarction of qi deficiency and blood stasis type
[目的]探究炙黄芪-水蛭联合阿加曲班注射液治疗气虚血瘀型急性脑梗死的疗效观察.[方法]选取2021年2 月—2023 年 2 月于本院进行急性脑梗死治疗的患者 110 例,按照随机数字表法将其分为阿加曲班注射液组(西药组)34 例、炙黄芪-水蛭组(中药组)36 例,以及联合组 40 例.西药组给予阿加曲班注射液;中药组给予炙黄芪-水蛭;联合组给予炙黄芪-水蛭联合阿加曲班注射液治疗.评估患者治疗前后中医证候积分水平;采用美国国立卫生研究院卒中量表(NIHSS)、改良Rankin(mRS)评分量表评估患者自身的神经功能缺损情况以及神经功能恢复情况;检测脑血流阻力指数(RI)、舒张期血流速度(Vd)、收缩期峰值流速(Vs)、平均血流速度(Vm)、血管内皮生长因子(VEGF)、一氧化氮(NO)水平.[结果]治疗后,联合组中医证候积分、NIHSS、mRS评分、RI、VEGF水平均低于西药组、中药组(P＜0.05);Vd、Vs、Vm、NO水平高于西药组、中药组(P＜0.05);联合组总有效率较高(P＜0.01).[结论]经炙黄芪-水蛭、阿加曲班注射液联合治疗,其气虚血瘀型急性脑梗死患者中医证候积分水平降低,相关神经功能、血流情况及血管内皮损伤情况均得到显著改善,临床治疗效果显著.
[Objective]To explore the curative effect of baked Astragalus Hirudo combined with Agattriban Injection in the treatment of acute cerebral infarction of qi deficiency and blood stasis type.[Methods]A total of 110 patients receiving acute cerebral infarction treatment in our hospital from February 2021 to February 2023 were selected and randomly divided into Agattriban injection group(Western medicine group)in 34 cases,baked Astragalus Hirudo group[the traditional Chinese medicine(TCM)group]in 36 cases,and combined group in 40 cases.The Western medicine group was given Agattriban Injection;the TCM group was treated with decocted baked Astragalus Hirudo;the combined group was treated with baked Astragalus Hirudo combined with Agattriban injection.Evaluate the TCM syndrome score level of patients before and after treatment;NIHSS score scale and mRS score scale were used to evaluate the neurological impairment and neurological function recovery of patients.Cerebral blood flow resistance index(RI),Diastolic blood flow velocity(Vd)and Peak systolic velocity(Vs),Mean blood flow velocity(Vm),Vascular endothelial growth factor(VEGF),and Nitric oxide(NO)levels were detected.[Results]After treatment,TCM syndrome score,NIHSS score,mRS score,RI and VEGF levels in combined group were lower than those in Western medicine group and TCM group(P＜0.05).The levels of Vd,Vs,Vm and NO were higher than those in Western medicine group and TCM group(P＜0.05).The total effective rate of combined group was higher(P＜0.01).[Conclusion]After combined treatment with baked Astragalus Hirudo and Agattriban injection,the TCM syndrome score level of patients with acute cerebral infarction of qi deficiency and blood stasis type was reduced,and related nerve function,blood flow and vascular endothelial injury were significantly improved,and the clinical therapeutic effect was significant.
王会品;张二锋;马骥
郑州市第三人民医院药学部,郑州 450000郑州市第三人民医院神经内科,郑州 450000
临床医学
急性脑梗死气虚血瘀炙黄芪-水蛭阿加曲班注射液临床疗效
acute cerebral infarctionqi deficiency and blood stasisbaked Astragalus HirudoAgattriban Injectionclinical effect
《天津中医药》 2024 (004)
422-426 / 5
河南省医学科技攻关计划项目(LHGJ20220829).
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