中国实用外科杂志2024，Vol.44Issue(3)：259-263,5.DOI:10.19538/j.cjps.issn1005-2208.2024.03.04
肝胆管结石形成中的生物力学机制
The biomechanical mechanisms in the formation of hepatic bile duct stones
摘要
Abstract
Hepatobiliary stones are one of the most difficult problems facing hepatobiliary surgery in China with high incidence,difficulty treatment,high recurrence rate,and lack of curative treatment method.Previous studies on the formation of hepatobiliary stones have mainly focused on their etiological factors,ignoring the role of biomechanics in the process.However,the mechanical properties of the biliary system are closely related to its physiopathologic functions.From the mechanical point of view,the biliary system is a"pump-tube structure",in which the hepatocyte is the source of bile synthesis,and bile is formed through mechanical osmosis of the capillary bile ducts,then flows through the bile ducts and is discharged into the intestines,with the gallbladder acting as a pump to provide the driving force,and the sphincter of Oddi acting as a valve.The stability of the"pump-tube structure"directly impacts the patency of the bile flow,thereby influencing the formation of hepatobiliary duct stones.Clarifuying the relationship between the mechanical properties of the biliary system and the formation of hepatobiliary duct stones,we can not only gain a deeper understanding of the causes of stone formation but also provide new ideas for future treatment methods.By adjusting the mechanical properties of the biliary system,we may be able to fundamentally prevent the formation of hepatobiliary duct stones,thus paving a new path for the treatment of hepatobiliary duct stones.关键词
胆管结石/流体力学/固体力学/胆汁淤积/力学模拟Key words
biliary stones/fluid dynamics/mechanical stress/cholestasis/mechanical simulation分类
医药卫生引用本文复制引用
曲凯,刘昌..肝胆管结石形成中的生物力学机制[J].中国实用外科杂志,2024,44(3):259-263,5.基金项目
国家自然科学基金面上项目(No.81972236) （No.81972236）
西安交通大学医学"基础-临床"融合创新项目(No.YXJLRH2022035) （No.YXJLRH2022035）
