肿瘤防治研究2024，Vol.51Issue(3)：169-177,9.DOI:10.3971/j.issn.1000-8578.2024.23.0986
铁死亡相关基因GLS2在泛癌中的预后及免疫价值
Role of Ferroptosis-related Gene GLS2 in Pan-cancer Prognosis and Immunity
摘要
Abstract
Objective To assess the role of the ferroptosis-associated gene GLS2 in the prognosis of pan-cancer and immunity using bioinformatics methods.Methods GLS2 expression levels in pan-cancer were profiled using publicly available databases:The Cancer Genome Atlas,GTEx,Cancer Cell Line Ency-clopedia and the International Cancer Genome Consortium.The aim was to explore the role of GLS2 gene expression,gene variation survival analysis,immune infiltration,immune checkpoint related genes,TMB,and MSI in different tumors.Results Difference in GLS2 expression levels between cancer and paraneoplastic tissues was statistically significant in most cancer types,and the expression level was correlated with survi-val in these cancer types.A positive correlation was found between GLS2 expression and immune cell infiltration in multiple cancer types,and GLS2 expression level was positively correlated with TMB,MSI,and methylation,and its expression is an indicator for potential therapeutic response.Conclusion Pan-cancer analysis shows that the ferroptosis-related gene GLS2 can be used as a diagnostic and prognostic marker of clear cell carcinoma of kidney,adrenocortical carcinoma,lung adenocarcinoma,and pancreatic cancer.关键词
铁死亡/GLS2/泛癌/预后/免疫Key words
Ferroptosis/GLS2/Pan-cancer/Prognosis/Immune分类
医药卫生引用本文复制引用
潘月眉,孙之,赵倩倩,胡雪雪,王传玺..铁死亡相关基因GLS2在泛癌中的预后及免疫价值[J].肿瘤防治研究,2024,51(3):169-177,9.基金项目
Natural Science Foundation of China(No.82172672) （No.82172672）
Natural Science Foundation of Shandong Province(No.ZR2021MH379) 国家自然科学基金面上项目(82172672) （No.ZR2021MH379）
山东省自然科学基金(ZR2021MH379) （ZR2021MH379）
