分析化学2024，Vol.52Issue(3)：306-312,7.DOI:10.19756/j.issn.0253-3820.221408
糖化白蛋白检测方法的研究进展
Progress of Methods for Detection of Glycated Albumin
摘要
Abstract
Diabetes mellitus,commonly called diabetes,is a group of chronic metabolic diseases characterized by the hyperglycemia over a prolonged period of time.Diabetes mellitus and its complications have become a serious global public health issue.Due to the lack of effective cure means,blood glucose monitoring has become an integral part of the diabetes management.As the product of the nonenzymatic glycation reaction between human serum albumin(HSA)and glucose in the blood,glycated albumin(GA)can effectively reflect the overall blood glucose level in the past two-three weeks.As a result,GA has been demonstrated to be a promising serum marker for the short-term glycemic control assessment,effectiveness evaluation,and therapy adjustment of diabetic patients.Accordingly,the simple,fast,low-cost,and highly sensitive and selective detection method for GA is of great value to diabetes management.In this review,a comprehensive overview of the progress on methods for GA detection was presented,with a focus on the detection principles and their respective advantages and disadvantages.Also,the prospect of the method for GA detection was presented.关键词
糖化白蛋白/糖化血红蛋白/糖尿病/血糖监测/非酶促糖基化/评述Key words
Glycated albumin/Glycated hemoglobin/Diabetes mellitus/Blood glucose monitoring/Nonenzymatic glycation/Review引用本文复制引用
胡琼,李诗琪,骆怡琳,曹晓静,梁伊依,冯文星,牛利..糖化白蛋白检测方法的研究进展[J].分析化学,2024,52(3):306-312,7.基金项目
广州市科技计划项目(Nos.202201010600,202201020170)、广州大学大学生创新训练项目(Nos.202211078113,S202111078031)和广东省基础与应用基础研究基金项目(No.2022A1515010618)资助. Supported by the Guangzhou Science and Technology Project(Nos.202201010600,202201020170),the Innovation Training Program for College Students of Guangzhou University(Nos.202211078113,S202111078031),and the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010618). （Nos.202201010600,202201020170）
