现代食品科技2024，Vol.40Issue(3)：9-17,9.DOI:10.13982/j.mfst.1673-9078.2024.3.0355
当归挥发油对小鼠抑郁行为的影响
Effects of Angelica sinensis Volatile Oil on Depressive Behavior in Mice
摘要
Abstract
To determine the effects and mechanism of Angelica sinensis volatile oil(ASVO)on depressive behavior,chronic unpredictable mild stress(CUMS)-induced depression mouse models were established.Mice were divided into normal,model,low-dose,medium-dose,and high-dose ASVO(15,30,and 60 mg/kg,respectively),and fluoxetine hydrochloride(2.1 mg/kg)groups.After four weeks of intervention,the number of central zone crossing,central zone activity duration,and sucrose preference were increased(P<0.01)while the tail suspension time was reduced(P<0.05,P<0.01)in all ASVO groups compared with those in the model group.The pathological changes in the hippocampal CA1 region were alleviated,and the contents of serum interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)decreased(P<0.01)while that of IL-10 increased(P<0.01).Despite no significant changes in the dopamine(DA)content and neurotrophin-3(NT-3)expression in the brain tissue of mice in the low-dose ASVO group(P>0.05),the contents of DA,norepinephrine(NE),and 5-hydroxytryptamine(5-HT)and the expression of nerve growth factor(NGF),NT-3,and brain-derived neurotrophic factor(BDNF)increased in the other groups(P<0.05,P<0.01).These results indicate that ASVO can improve CUMS-induced depressive behavior in mice,which is related to the inhibition of neuroinflammation,upregulation of monoamine neurotransmitter contents,and promotion of neurotrophic factor expression.关键词
当归挥发油/抑郁/炎症/单胺类神经递质/神经营养因子Key words
Angelica sinensis volatile oil/depression/inflammation/monoamine neurotransmitters/neurotrophic factor引用本文复制引用
谢云亮,张博..当归挥发油对小鼠抑郁行为的影响[J].现代食品科技,2024,40(3):9-17,9.基金项目
吉林省教育厅科技项目(JJKH20210059KJ （）
JJKH20210055KJ) （）
