海南医学院学报2024，Vol.30Issue(7)：555-560,6.DOI:10.13210/j.cnki.jhmu.20230811.004
细胞自噬对肝纤维化的影响及中医药治疗进展
The influence of autophagy on liver fibrosis and the progress of TCM treatment
摘要
Abstract
Autophagy is an important process of cell growth,survival and homeostasis.The disorder of autophagy is in-volved in the occurrence and development of many diseases.According to the pathway by which the degradation components caused by autophagy reach the lysosomes,autophagy can be divided into macroautophagy,microautophagy and chaperon-mediated autophagy.Among them,macroautophagy is a more widely studied form of cellular autophagy,which plays an important role in the occurrence and development of liver fibrosis.The role of autophagy in liver fibrosis depends on the type of cells and the stage of the disease,so regulation of autophagy may provide a new therapeutic strategy for reversing liver fibrosis.De-cades of research has proved that traditional Chinese medicine has outstanding effects in the treatment of liver fibrosis and can im-prove the reversal rate of liver fibrosis.In recent years,many Chinese herbal compounds have been reported to regulate autophagy and improve liver fibrosis.It is important to clarify the significance of autophagy on liver fibrosis and the understanding of TCM the-ory on autophagy and liver fibrosis.This article mainly discusses the influence of autophagy on liver fibrosis and the progress of Chi-nese medicine regulation of autophagy on anti-liver fibrosis treatment.关键词
细胞自噬/肝纤维化/分子机制/相关通路/中医药/进展Key words
Autophagy/Liver fibrosis/Molecular mechanism/Correlation path/Traditional Chinese medicine/Progress分类
医药卫生引用本文复制引用
牛丽娜,刘云霄,窦婧,张冰,隆强,徐强,王晓忠..细胞自噬对肝纤维化的影响及中医药治疗进展[J].海南医学院学报,2024,30(7):555-560,6.基金项目
新疆医科大学附属中医医院院级重点项目(ZYY2023ZD4) （ZYY2023ZD4）
国家自然科学基金(81760832) （81760832）
新疆维吾尔自治区自然科学基金项目(2022D01C173) （2022D01C173）
乐德行全国名中医传承工作室创新项目This study was supported by Hospital Level Key Project of Xinjiang Medical University Affiliated Hospital of Traditional Chinese Medicine(ZYY2023ZD4) （ZYY2023ZD4）
National Natural Science Foundation of China(81760832) （81760832）
Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01C173) （2022D01C173）
LE Dexing National Famous Traditional Chinese Medicine Inheritance Studio Innovation Project （）
