解放军医学杂志2024，Vol.49Issue(3)：302-307,6.DOI:10.11855/j.issn.0577-7402.2030.2023.0630
基于倾向性评分逆概率加权法的视网膜母细胞瘤疗效评价及其预后影响因素分析
Efficacy evaluation and prognostic factors analysis of retinoblastoma based on propensity score inverse probability weighting method
石丽娟 1李丽 1石福艳 2周希彬 3吴志鸿3
作者信息
- 1. 潍坊医学院临床医学院眼科学教研室,山东潍坊 261053||解放军总医院第三医学中心眼科医学部,北京 100039
- 2. 潍坊医学院公共卫生学院卫生统计学教研室,山东潍坊 261053
- 3. 解放军总医院第三医学中心眼科医学部,北京 100039
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of surgery,chemotherapy and surgery combined chemotherapy for retinoblastoma(RB),and analyze the prognostic factors of RB patients.Methods Clinical data of 1188 RB patients registered in the Surveillance,Epidemiology and End Results(SEER)database from January 2000 to December 2019 were retrospectively analyzed.The baseline characteristics of patients treated with surgery,chemotherapy or surgery combined with chemotherapy were balanced by inverse probability of treatment weighting(IPTW).Log-rank test analysis was used to compare the survival probability of patients in the 3 groups,and Cox regression models were used to analyse the factors influencing the prognosis of RB patients.Results A total of 1188 RB cases were included in this study,including 426 cases in surgery group,200 cases in chemotherapy group and 562 cases in surgery combined with chemotherapy group.After IPTW weighting,baseline data such as age,sex and race were balanced(P＞0.05).Log-rank test results showed that the survival curves of the three groups were significantly different before and after weighting(P＜0.05).After weighted,the survival of patients in surgery group was significantly better than that in chemotherapy group and surgery combined chemotherapy group(P＜0.05),and there was no statistical significance between chemotherapy group and surgery combined chemotherapy group(P＞0.05).The weighted patient survival probability at 1st,3rd and 5th years were 99.7%,98.9%and 98.6%in surgery group;97.4%,95.8%and 95.8%in chemotherapy group;and 97.9%,95.8%and 95.0%in surgery combined chemotherapy group.Cox regression analysis showed that compared with surgery group,the specific risk ratio of death was 1.367(95%CI 1.100-1.700)in chemotherapy group and 1.132(95%CI 0.963-1.330)in combined chemotherapy group.Compared with patients with 1 RB lesion,the patient-specific mortality risk ratio for patients with 2 or more RB lesions was 0.399(95%CI 0.268-0.594).Conclusions Patients with RB have higher survival rates probability after treatment.After controlling the influence of age,sex and other factors,the effect of surgery was better among the three treatment methods.Multifocality may be an independent prognostic factor in RB patients.关键词
视网膜母细胞瘤/逆概率加权/疗效/生存分析Key words
retinoblastoma/inverse probability of treatment weighting/efficacy/survival analysis分类
医药卫生引用本文复制引用
石丽娟,李丽,石福艳,周希彬,吴志鸿..基于倾向性评分逆概率加权法的视网膜母细胞瘤疗效评价及其预后影响因素分析[J].解放军医学杂志,2024,49(3):302-307,6.
