临床肝胆病杂志2024，Vol.40Issue(4)：816-821,6.DOI:10.12449/JCH240428
微球和纳米颗粒在经动脉化疗栓塞治疗肝细胞癌中的应用
Advances in the application of microspheres and nanoparticles in transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma
摘要
Abstract
In recent years,transcatheter arterial chemoembolization(TACE)has emerged as a common treatment modality for the treatment of hepatocellular carcinoma(HCC).However,with the ongoing development of embolic agent techniques,the new advances in microspheres and nanoparticles have brought new hope for improving the efficacy and safety of TACE.This article reviews the latest advances and applications of microspheres and nanoparticles in TACE for HCC.First,this article introduces the background of TACE as a therapeutic approach and the emergence of microsphere and nanoparticle techniques,and then it describes the application of various types of microspheres and nanoparticles in TACE and discusses the requisite attributes of an ideal embolic agents.The article focuses on the advances in material science and engineering,as well as the clinical efficacy of drug-eluting microspheres and nanoparticles versus conventional TACE.Furthermore,it discusses the importance of radiological examination in TACE and summarizes the research advances in the radiopaque and magnetic resonance-visible embolic agents.This article also explores the future development directions and challenges of TACE.It also points out the combination of microspheres and nanoparticles with other treatment modalities,the application of personalized and precision medicine in TACE,and the potential regimen of TACE in clinical translation,and meanwhile,it raises the issues of ethics and regulation that need to be further discussed.It is believed that microspheres and nanoparticles have a potential effect in TACE,which provides a theoretical basis and technical support for innovating HCC treatment regimens and improving the prognosis of patients through TACE interventions.关键词
微球/纳米球/癌,肝细胞/化学栓塞,治疗性Key words
Microspheres/Nanospheres/Carcinoma,Hepatocellular/Chemoembolization,Therapeutic引用本文复制引用
张楚悦,史家宁,王明达,吴寒,史立军,杨田..微球和纳米颗粒在经动脉化疗栓塞治疗肝细胞癌中的应用[J].临床肝胆病杂志,2024,40(4):816-821,6.基金项目
国家自然科学基金(82273074)National Natural Science Foundation of China(82273074) （82273074）
