临床神经病学杂志2024，Vol.37Issue(2)：109-112,4.
以双侧颅神经麻痹为临床表现的鼻眶脑毛霉菌病的临床特点(附1例报告)
Clinical features of rhino-orbital-cerebral mucormycosis with bilateral cranial nerves paralyze as the clinical manifestation(report of one case)
摘要
Abstract
Objective To investigate the clinical features of rhino-orbital-cerebral mucormycosis(ROCM)with bilateral cranial nerve palsies as the clinical manifestation.Methods The related clinical data about ROCM with bilateral cranial nerve palsy as a clinical manifestation was collected,analyzed as well as discussed in the manuscript.And the relevant literatures were reviewed.Results This patient was a healthy young man with new-onset diabetes and diabetic ketoacidosis.The patient developed rapidly with acute onset,bilateral blindness,blepharoptosis and extraocular muscle paralysis.The presence of mucormycosis was confirmed by CSF second-generation sequencing,fungal fluorescent staining and culture.Although effective antifungal therapy was performed early,but the patient quickly presented with cerebral hemorrhage and herniation.Eventually,the patient died after discharge.Conclusions ROCM is a rare and high-mortality infectious disease.This case indicated that the clinicians should consider the presence of ROCM in patients with diabetes/diabetic ketoacidosis when the bilateral cranial nerves paralysis are the clinical symptom,whicn can not be explained by other lesions.CSF next-generation sequencing is helpful for rapid diagnosis.关键词
鼻眶脑毛霉菌病/双侧颅神经麻痹/脑出血/二代测序/糖尿病酮症酸中毒Key words
rhino-orbito-cerebral mucormycosis/bilateral cranial nerves paralysis/brain herniation/next-generation sequencing/diabetic ketoacidosis分类
医药卫生引用本文复制引用
郑晓彧,杨洪娜,方巍..以双侧颅神经麻痹为临床表现的鼻眶脑毛霉菌病的临床特点(附1例报告)[J].临床神经病学杂志,2024,37(2):109-112,4.基金项目
国家自然科学基金(81701057) （81701057）
