中南医学科学杂志2024，Vol.52Issue(2)：228-231,4.DOI:10.15972/j.cnki.43-1509/r.2024.02.017
替勃龙治疗绝经后女性耳鸣的疗效及对其神经递质水平和睡眠质量的影响
Efficacy of tibolone on postmenopausal tinnitus women and its effect on neurotransmitter lev-els and sleep quality
摘要
Abstract
Aim To explore the efficacy of tibolone in postmenopausal women with tinnitus and its effect on neurotransmitter levels and sleep quality.Methods 106 patients with postmenopausal tinnitus admitted were randomly divided into control group(n=53)and observation group(n=53).Both groups received comprehensive management of perimenopausal period.The control group took oryzanol tablets orally,and the observation group took tibolone tablets orally+oryzanol tablets orally.The clinical efficacy,Kupperman menopause index(KMI),Tinnitus handicap index(THI),Pittsburgh sleep quality index(PSQI)score and serum estra-diol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH),5-hydroxytryptamine(5-HT),norepinephrine(NE)levels before and after treatment were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the KMI,THI,and PSQI scores of both groups decreased,and the observation group was lower than the control group;The serum E2 and 5-HT levels in both groups increased,and the observation group was higher than the control group.The FSH,LH,and NE levels in both groups decreased,and the obser-vation group was lower than the control group(P<0.05).Conclusion Tibolone can significantly improve tinnitus symptoms and sleep quality in postmenopausal women,and the regulation of sex hormones,neurotransmitter levels may be its mechanism of action.关键词
激素替代治疗/替勃龙/绝经后女性/耳鸣/神经递质/睡眠质量Key words
hormone replacement therapy/tibolone/postmenopausal women/tinnitus/neurotransmitters/sleep quality分类
医药卫生引用本文复制引用
王宾红,蔡杰,张玥红..替勃龙治疗绝经后女性耳鸣的疗效及对其神经递质水平和睡眠质量的影响[J].中南医学科学杂志,2024,52(2):228-231,4.基金项目
北京市通州区科技计划项目(KJ2019CX011) （KJ2019CX011）
