Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)OA北大核心

BACKGROUND The association of cardiovascular risk burden with disability is unclear.We examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older adults. METHODS A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012-2016 and without a history of stroke or coronary heart disease at baseline and follow-up were included.FGCRS at baseline was assessed and categorized into tertiles.Physical function was evalu-ated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects models. RESULTS At baseline,FGCRS ranged between 3-94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,respectively.In the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012-2014(P = 0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed re-gions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05). CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in gait.Res-ults suggest SPPB may provide a measure of cardiovascular health in older adults.