孕期膳食维生素B3摄入与子痫前期及临床亚型发生风险的关系OACSTPCD

Objective:To explore the relationship between dietary vitamin B3 intake during pregnancy and the risk of preeclampsia(PE)and its clinical subtypes,so as to provide reference for the effective implementation of PE nursing intervention.Methods:A total of 9 350 pregnant women who gave birth in the obstetrics department of a tertiary class A hospital from March 2012 to September 2016 were selected as the research objects.General demographic characteristics and dietary intake during pregnancy were collected.The effects of dietary vitamin B3 intake during pregnancy on the risk of PE and its clinical subtypes were analyzed by unconditioned logistic regression model.Results:Dietary vitamin B3 intake during pregnancy was associated with the risk of PE development.Dietary vitamin B3 intake at≥13.70 mg/d、13.74 mg/d levels during the first and second trimesters was a protective factor for early-onset preeclampsia(EOPE).9.65～<13.74 mg/d、9.63～<13.72 mg/d levels during the second and third trimesters were a protective factor for late-onset preeclampsia(LOPE).In pregnant women with normal pre-pregnancy BMI,vitamin B3 intake reaching≥13.70 mg/d level in early pregnancy could reduce the risk of EOPE.9.65～<13.74 mg/d、9.63～<13.72 mg/d levels during the second and third trimesters reduced the risk of LOPE.In pregnant women with pre-pregnancy BMI≥24.0 kg/m2,vitamin B3 intake at 9.45～<13.70 mg/d、9.65～<13.74 mg/d、9.63～<13.72 mg/d level during early,the second and third trimesters were associated with a lower risk of LOPE.Conclusions:Dietary vitamin B3 intake in pregnant women with different pre-pregnancy BMI was associated with the incidence of PE and its clinical subtypes.Medical staff should guide pregnant women to practice self-care,strengthen monitoring of pre-pregnancy BMI,and ensure adequate intake of dietary vitamin B3 for pregnant women,thereby reducing the risk of developing PE.