中国医科大学学报2024，Vol.53Issue(3)：213-217,5.DOI:10.12007/j.issn.0258-4646.2024.03.004
主肺动脉收缩期加速时间/射血时间比值评估重度子痫前期胎儿肺成熟度
Assessment of fetal lung maturity in severe preeclampsia using main pulmonary artery accelerated systolic time/ejection time ratio
摘要
Abstract
Objective To investigate the assessment of fetal lung maturity using main pulmonary artery accelerated systolic time(AT)/ejection time(ET)ratio in patients with severe preeclampsia.Methods A total of 65 pregnant women who were hospitalized in our hos-pital due to severe preeclampsia,from January 2021 to December 2022,and voluntarily underwent ultrasound examination were enrolled in this study.The patients were divided into early-onset(20 to 33+6 weeks gestation)severe preeclampsia group(group A,n= 30)and late-onset(34 to 40 weeks)severe preeclampsia group(group B,n= 35).Healthy pregnant women with gestational age-matched to groups A and B via ultrasound examination were selected as controls(n= 30 andn= 35,respectively).Fetal main pulmonary artery blood flow parameters were measured using ultrasound Doppler:AT,ET,AT/ET,and peak systolic flow rate(PSV).Amniotic fluid(approximately 15 mL)was collected immediately after delivery,and the lecithin/sphingomyelin(L/S)values were measured.The blood flow parameters of the main pulmonary artery of the fetuses in groups A and B were compared,and whether there was any difference between them and the control group was analyzed.The correlation between the blood flow parameters and amniotic fluid L/S was also analyzed.Results There were statistically significant differences in AT,ET,AT/ET,and PSV in the fetal main pulmonary artery between groups A and group B(P＜0.05),and all of them were smaller than those in the control group(P＜0.05).The AT/ET ratio of the fetal main pulmonary artery in groups A and B was positively correlated with amniotic fluid L/S(r= 0.821 and 0.383,respectively,P＜0.05).Receiver operating charac-teristic curve analysis showed that the area under the curve of AT/ET in the diagnosis of early-onset and late-onset preeclampsia was 0.839 and 0.833,respectively,and the sensitivity was 0.853 and 0.912,the specificity was 0.583 and 0.611,and the cut-off values were 0.185 and 0.255,respectively.The false positive rate was 5%.Conclusion The AT/ET value of the fetal main pulmonary artery can be used to make a preliminary diagnosis of severe preeclampsia and quantitatively assess fetal lung maturity,which can provide a new,simple,non-invasive,and reproducible assessment method for clinical practice.关键词
超声检查/重度子痫前期/胎儿肺成熟度/主肺动脉Key words
ultrasonography/severe preeclampsia/fetal lung maturity/main pulmonary artery分类
医药卫生引用本文复制引用
田飞,窦连峰,唐丽玮,刘玉芳..主肺动脉收缩期加速时间/射血时间比值评估重度子痫前期胎儿肺成熟度[J].中国医科大学学报,2024,53(3):213-217,5.基金项目
山东省自然科学基金(ZR2021MH247) （ZR2021MH247）
山东省医药卫生科技发展计划项目(202005020624) （202005020624）
