普罗布考联合他汀类药物治疗颈动脉斑块的meta分析OACSTPCD

Objective To investigate the efficacy of probucol combined with statins in the treatment of carotid plaque. Methods Using"probucol""statin""carotid artery"as the keywords,Chinese databases CNKI,VIP and WanFang,English databases PubMed,Cochrane Library and Embase were searched.Screening randomized controlled trials of probucol combined with statins for carotid plaque.The search period was from the establishment of the database until December 17,2023.Statin therapy alone was the control group,and statin therapy combined with probucol was the combined group.The quality of included studies was assessed with reference to Cochrane bias risk assessment.The main outcome measures included the average carotid artery intima-media thickness(IMT),secondary outcome indicators included TC,hs-CRP,stroke events,etc.Meta-analysis was performed using RevMan 5.1 software. Results Eleven randomized controlled trials with a total of 3251 patients were included.Meta-analysis showed that the combined group was superior to the control group in reducing IMT[standardized mean difference(SMD)-0.93,95％CI-1.66--0.20,P＜0.001].The combined group was better than the control group in reducing TC level(SMD-1.08,95％CI-1.60--0.55,P＜0.001).There was no significant difference in reducing hs-CRP level between the two groups(SMD-1.22,95％CI-2.48-0.04,P=0.060).The combined group was superior to the control group in reducing stroke events(RR 0.34,95％CI 0.17-0.65,P=0.001). Conclusions Probucol combined with statins is more effective in the treatment of carotid plaque,and can reduce the level of TC and the incidence of stroke events.