七氟烷与丙泊酚对腹腔镜手术患者认知功能、呼吸循环以及应激反应的影响OA

Objective:To investigate the effects of sevoflurane and propofol on cognitive function,respiration and circulation and stress response in patients undergoing laparoscopic surgery.Methods:A total of 116 patients undergoing laparoscopic surgery in a hospital from January 2021 to January 2022 were divided into the propofol group and sevoflurane group by random number table method,with 58 patients in each group.The propofol group was anesthetized with propofol injectable emulsion,and the sevoflurane group was anesthetized with sevoflurane for inhalation.The general indexes(the amount of intraoperative blood transfusion,onset time of anesthesia and respiratory recovery time),respiratory and circulatory functions[heart rate(HR),mean arterial pressure(MAP)and oxygen saturation(SO2)],stress-related indexs[blood glucose,plasma adrenaline,adrenocorticotropic hormone(ACTH)and cortisol],cognitive function[neuron specific enolase(NSE),mini-mental state examination(MMSE)]and complications were observed between the two groups.Results:There was no statistically significant difference in the amount of intraoperative blood transfusion or the onset time of anesthesia between the two groups(P>0.05).The respiratory recovery time in the sevoflurane group was shorter than that in the propofol group(P<0.05).There was no statistically significant difference in HR,MAP or SO2 between the two groups before anesthesia induction,after anesthesia induction,at 10min after induction,at 20min after induction or at 30min after induction(P>0.05),without statistically significant difference across timepoints between the two groups(P>0.05).The levels of blood glucose,plasma adrenaline,ACTH and cortisol in the sevoflurane group were lower than those in the propofol group immediately after surgery,and at 6h,24h and 48h after the surgery(P<0.05).The serum NSE level in the sevoflurane group was higher than that in the propofol group at 6h,24h and 48h after surgery(P<0.05),while the MMSE score in the sevoflurane group was lower than that in the propofol group(P<0.05).There was no statistically significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion:There is no significant difference in respiratory and circulatory functions between anesthesia with sevoflurane and propofol in elderly patients undergoing laparoscopic surgery,but propofol has less effect on cognitive function,and sevoflurane is superior in inhibiting stres response.