中国医科大学学报2024，Vol.53Issue(3)：193-197,206,6.DOI:10.12007/j.issn.0258-4646.2024.03.001
持续输注超低剂量右美托咪定对老年CAS患者血流动力学和术后认知功能的影响
Effects of continuous infusion of extremely low-dose dexmedetomidine on the hemodynamic stability and postoperative neurological function of older adult patients undergoing CAS
摘要
Abstract
Objective To investigate the effects of continuous infusion of extremely low-dose dexmedetomidine on the hemodynamic sta-bility and recovery of postoperative cognition of older adult patients undergoing carotid artery stenting(CAS).Methods 106 older adult patients undergoing CAS were randomly divided into the dexmedetomidine(group D,n= 52)and control groups(group C,n= 54).Hemo-dynamic and cerebral perfusion changes were recorded 15 min before anesthesia induction(T0),5 min after anesthesia induction(T1),5 min before stent placement(T2),5 min after stent placement(T3),and 5 min after tracheal extubation(T4).The standard deviations(SD)of mean arterial pressure(MAP),heart rate(HR),and regional cerebral oxygen saturation(rSO2)were calculated as SDMAP,SDHR,and SDrSO2,respectively.The Montreal Cognitive Assessment Scale(MoCA)was used to evaluate and compare changes in pre-and post-operative cognitive function and examine the incidence of postoperative cognitive dysfunction(POCD)in the two groups.Results SDMAP,SDHR,and SDrSO2 in group D were significantly lower than those in group C(P＜0.05).The applied dosages of anesthetics and vasoactive drugs were significantly lower in group D than C(P＜0.05).Extubation time in group D was significantly shorter than that in group C(P＜0.05).MoCA scores in group D were significantly higher one day after CAS than that in group C and POCD incidence was significantly lower in group D one month after CAS(P＜0.05).Conclusion Continuous infusion of low-dose dexmedetomidine has the potential to maintain hemodynamic stability and cerebral perfusion,reduce the dosage of anesthetic drugs,and improve postoperative cognitive performance in older adult patients.关键词
右美托咪定/颈动脉支架置入术/血流动力学/术后认知功能障碍Key words
dexmedetomidine/carotid artery stenting/hemodynamics/postoperative cognitive dysfunction分类
医药卫生引用本文复制引用
王晓宁,张丽红,张彤,李天佐..持续输注超低剂量右美托咪定对老年CAS患者血流动力学和术后认知功能的影响[J].中国医科大学学报,2024,53(3):193-197,206,6.基金项目
国家重点研发项目(2018YFC2001805) （2018YFC2001805）
