CT理论与应用研究2024，Vol.33Issue(3)：333-342,10.DOI:10.15953/j.ctta.2022.242
基于能谱CT碘图的影像组学诊断甲状腺乳头状癌颈部淋巴结转移的价值
The Value of Radiomics Based on Spectral CT Iodine Map for Diagnosing Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma
摘要
Abstract
Objective:To investigate the value of radiomics features based on spectral CT iodine map for diagnosing metastatic cervical lymph nodes in patients with papillary thyroid carcinoma.Methods:Seventy-eight patients with papillary thyroid carcinoma who underwent cervical energy spectrum CT within two weeks before surgery were retrospectively analyzed.We included 117 metastatic,176 non-metastatic lymph nodes,which were then randomly divided into a training set and a validation set in a 3:1 ratio.Radiomics features were extracted and screened from venous phase iodine maps.Logistic regression model was used to construct diagnostic models based on CT image features,radiomics signature,and a combination of the two,respectively;a nomogram was then drawn to visualize the combined model.The diagnostic performance,calibration ability and clinical practicability of each model were evaluated by ROC curve,calibration curve and decision curve analysis,respectively.Results:The combined model showed optimal diagnostic performance in both the training and validation sets,followed by radiomics model.These two models outperformed the CT image features model in both the training and validation sets.All models showed good calibration,and decision curve analysis demonstrated the superiority of the nomogram over the other two models in terms of clinical usefulness.Conclusion:The radiomics signature of spectral CT showed good performance in diagnosing lymph node metastasis of papillary thyroid carcinoma.The diagnostic performance was further improved when combined with CT image features,which can be a useful tool to assist in clinical decision-making.关键词
能谱CT/影像组学/甲状腺肿瘤/乳头状癌/淋巴结转移Key words
spectral CT/radiomics/thyroid neoplasms/papillary carcinoma/lymphatic metastasis分类
医药卫生引用本文复制引用
王锐,金丹,徐亮,倪晓琼,王业青,范国华..基于能谱CT碘图的影像组学诊断甲状腺乳头状癌颈部淋巴结转移的价值[J].CT理论与应用研究,2024,33(3):333-342,10.基金项目
放射医学与辐射防护国家重点实验室开放课题(基于光谱CT评估肺癌放疗后急性放射性肺损伤研究(GZK12023041)). （基于光谱CT评估肺癌放疗后急性放射性肺损伤研究(GZK12023041）
