CT理论与应用研究2024，Vol.33Issue(3)：351-358,8.DOI:10.15953/j.ctta.2023.217
不同预后的抗MDA5抗体阳性IIMs患者肺部HRCT定量指标与临床研究
Quantitative Indexes and Clinical Studies of Lung HRCT in Patients with Anti-MDA5 Antibody-positive Iims with Different Prognoses and Clinical Studies
张明霞 1李玲 1高兰 2王玉华 2孙莹 1孙磊 1霍萌 1张春燕 1王仁贵1
作者信息
- 1. 首都医科大学附属北京世纪坛医院 放射科,北京 100038
- 2. 首都医科大学附属北京世纪坛医院 风湿免疫科,北京 100038
- 折叠
摘要
Abstract
Objective:To compare the quantitative parameters of lung HRCT and clinical manifestations of anti-melanoma differentiation-associated gene 5(MDA5)antibody-positive idiopathic inflammatory myopathy(IIM)patients with different prognoses.Methods:The clinical and imaging data of 19 MDA5 antibody-positive IIM patients admitted to Beijing Shijitan Hospital Affiliated with Capital Medical University between February 2017 and November 2022 were retrospectively analyzed.According to the prognoses,the patients were divided into the good prognoses group(14 cases)and the poor prognoses(intubation or death)group(5 cases).The clinical and laboratory indexes,types of interstitial lung disease(ILD),and CT quantitative indexes were compared between the two groups.Results:There were significant differences in gender;carcinoembryonic antigen;blood oxygen saturation;and the percentages of lymphocytes,monocytes,neutrophils,lymphocytes,and neutrophils between the good versus the poor prognoses groups.The proportion of abnormal respiratory system changes was higher in the poor prognoses group.In terms of the type of ILD,acute interstitial pneumonia(AIP)-like lesions were the main type in the poor prognoses group,and nonspecific interstitial pneumonia(AIP)lesions were the main type in the good prognoses group.For NSIP-like lesions,there was a statistically significant difference between the two groups.The semi-quantitative score of the poor prognoses group was higher,and the volume of whole lung lesions as well as the proportion of whole lung lesions were also higher.Spearman correlation analysis showed that the blood oxygen saturation,monocyte percentage,semi-quantitative score,whole lung lesion volume,and proportion of whole lung lesion were negatively correlated,while carcinoembryonic antigen,neutrophil percentage,and neutrophils were positively correlated with the semi-quantitative score,whole lung lesion volume,and proportion of whole lung lesion.Conclusions:The lung HRCT quantitative indicators,clinical manifestations,and laboratory indicators are different in MDA5 antibody-positive IIM patients with different prognoses.Early evaluation of HRCT imaging manifestations,clinical manifestations,and laboratory indicators is of great significance in determining the prognosis of MDA5 antibody-positive IIM patients,which provides corresponding support for clinical diagnosis and treatment.关键词
HRCT/特发性炎性肌病/IIMs/抗MDA5抗体/ILDKey words
HRCT/idiopathic inflammatory myopathies/IIMs/Anti-mda5 antibody/ILD分类
医药卫生引用本文复制引用
张明霞,李玲,高兰,王玉华,孙莹,孙磊,霍萌,张春燕,王仁贵..不同预后的抗MDA5抗体阳性IIMs患者肺部HRCT定量指标与临床研究[J].CT理论与应用研究,2024,33(3):351-358,8.
