健康人鼻腔及鼻咽腔颗粒沉降的生物力学研究OACSTPCD
Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy individual
目的 建立健康人鼻腔及鼻咽腔有限元数值模型,分析不同条件下鼻腔及鼻咽腔的颗粒沉降特征,从生物力学角度探讨颗粒沉降的影响因素,为临床鼻腔及鼻咽腔疾病的潜在诱发因素及经鼻腔给药方式提供参考.方法 采集志愿者鼻部多层螺旋CT数据,重建上呼吸道三维数值模型后,针对不同气流流率、颗粒粒径及颗粒密度条件下的颗粒沉降进行数值模拟.结果 鼻阈、鼻甲前端、鼻咽顶后壁为颗粒最易沉降区域.当气流流率为30 L/min及60 L/min时,不同颗粒直径、颗粒密度下该重建模型沉积率均可达80%以上.当颗粒粒径为10 μm及15 μm时,不同气流流率、颗粒密度下该重建模型沉积率均可达90%以上.结论 (1)颗粒在鼻腔主要沉降于鼻阈及鼻前庭,在鼻咽腔则主要沉降于鼻咽顶后壁;(2)气流速度、颗粒粒径及密度对颗粒沉积率均有影响,其中颗粒粒径对颗粒沉降影响最大,其次是气流流率、颗粒密度;(3)当颗粒密度及气流流率不变,相较于10 μm和15 μm的颗粒,直径为5 μm的颗粒在鼻咽部颗粒沉降最多.
OBJECTIVE To establish a finite element numerical model of the nasal and nasopharyngeal cavities of healthy people,analyze the particle deposition characteristics of the nasal and nasopharyngeal cavities under different conditions,and explore the influencing factors of particle deposition from the biomechanical point of view,so as to provide a reference for the potential predisposing factors of clinical nasal and nasopharyngeal diseases and the way of transnasal drug delivery.METHODS The multilayer spiral CT data of the nose of volunteers were collected,and after reconstructing the three-dimensional numerical model of the upper respiratory tract,numerical simulations of particle deposition were performed under different conditions of airflow rates,particle sizes and particle densities.RESULTS The threshold of the nose,the anterior end of the turbinate,and the posterior wall of the roof of the nasopharynx were the regions where particles were most likely to deposit.When the airflow rate was 30 L/min and 60 L/min,the deposition rate of the reconstructed model could reach more than 80%under different particle diameters and particle densities.When the particle size is 10 μm and 15 μm,the deposition rate of the reconstruction model can reach more than 90%under different airflow rates and particle densities.CONCLUSION 1.Particles in the nasal cavity mainly deposited in the nasal threshold and nasal vestibule,while in the nasopharyngeal cavity,they mainly deposited in the posterior wall of the nasopharyngeal roof;2.The airflow rate,particle size,and density all had an effect on the deposition rate of particles,with particle size having the greatest effect on particle deposition,followed by the airflow rate,and particle density;3.When the particle density and the airflow rate were unchanged,the deposition rate of the particles with the diameter of 5 μm could reach 80%or more in the nasopharyngeal cavity,compared to that of particles with diameters of 10 μm and 15 μm,with different airflow rates and particle densities.
杨花;孙东;苏英锋;孙秀珍;于申;唐媛媛
大连医科大学附属第二医院耳鼻咽喉科,辽宁 大连 116027||四川大学华西第二医院小儿耳鼻咽喉科,四川 成都 610041四川大学华西第二医院小儿耳鼻咽喉科,四川 成都 610041大连理工大学工业装备结构分析国家重点实验室,辽宁 大连 116023
鼻腔鼻咽生物力学颗粒沉降
Nasal CavityNasopharynxbiomechanicsparticle deposition
《中国耳鼻咽喉头颈外科》 2024 (003)
161-166 / 6
国家自然科学基金(81700874、11472074、12172082);大连医科大学附属第二医院院内培育项目(XJ2023000603)
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