中国耳鼻咽喉头颈外科2024，Vol.31Issue(3)：161-166,6.DOI:10.16066/j.1672-7002.2024.03.006
健康人鼻腔及鼻咽腔颗粒沉降的生物力学研究
Biomechanical study of particle deposition in the nasal and nasopharyngeal cavities of healthy individual
摘要
Abstract
OBJECTIVE To establish a finite element numerical model of the nasal and nasopharyngeal cavities of healthy people,analyze the particle deposition characteristics of the nasal and nasopharyngeal cavities under different conditions,and explore the influencing factors of particle deposition from the biomechanical point of view,so as to provide a reference for the potential predisposing factors of clinical nasal and nasopharyngeal diseases and the way of transnasal drug delivery.METHODS The multilayer spiral CT data of the nose of volunteers were collected,and after reconstructing the three-dimensional numerical model of the upper respiratory tract,numerical simulations of particle deposition were performed under different conditions of airflow rates,particle sizes and particle densities.RESULTS The threshold of the nose,the anterior end of the turbinate,and the posterior wall of the roof of the nasopharynx were the regions where particles were most likely to deposit.When the airflow rate was 30 L/min and 60 L/min,the deposition rate of the reconstructed model could reach more than 80%under different particle diameters and particle densities.When the particle size is 10 μm and 15 μm,the deposition rate of the reconstruction model can reach more than 90%under different airflow rates and particle densities.CONCLUSION 1.Particles in the nasal cavity mainly deposited in the nasal threshold and nasal vestibule,while in the nasopharyngeal cavity,they mainly deposited in the posterior wall of the nasopharyngeal roof;2.The airflow rate,particle size,and density all had an effect on the deposition rate of particles,with particle size having the greatest effect on particle deposition,followed by the airflow rate,and particle density;3.When the particle density and the airflow rate were unchanged,the deposition rate of the particles with the diameter of 5 μm could reach 80%or more in the nasopharyngeal cavity,compared to that of particles with diameters of 10 μm and 15 μm,with different airflow rates and particle densities.关键词
鼻腔/鼻咽/生物力学/颗粒沉降Key words
Nasal Cavity/Nasopharynx/biomechanics/particle deposition引用本文复制引用
杨花,孙东,苏英锋,孙秀珍,于申,唐媛媛..健康人鼻腔及鼻咽腔颗粒沉降的生物力学研究[J].中国耳鼻咽喉头颈外科,2024,31(3):161-166,6.基金项目
国家自然科学基金(81700874、11472074、12172082) （81700874、11472074、12172082）
大连医科大学附属第二医院院内培育项目(XJ2023000603) （XJ2023000603）
