广州化学2024，Vol.49Issue(2)：52-56,5.DOI:10.16560/j.cnki.gzhx.20240218
乙腈与吡咯苯胺构筑喹喔啉的[5+1]环化反应
Acetonitrile and Pyrrolidine Construct[5+1]Cyclization Reaction of Quinoxaline
万佳 1李珍珍 1刘珊珊1
作者信息
- 1. 陕西科技大学 化学与化工学院,陕西 西安 710021
- 折叠
摘要
Abstract
A[5+1]cyclization reaction involving acetonitrile was developed to synthesize quinoxaline derivatives.Using pyrrolidine as substrate and acetonitrile as both solvent and reagent,the[5+1]cyclization of pyrrolidine[1,2-a]quinoxaline molecules was achieved without additional metal catalyst.After a series of screening conditions,the optimal reaction conditions were as follows:p-methylbenzenesulfonic acid monohydrate(3 eq)as catalyst,H2O(5 eq),acetonitrile as solvent(0.5 mL),reaction at 140℃for 14 hours,the highest yield of 85%.In addition to pyrrolidine,a series of different guiding groups are successfully compatible,and the reaction can be applied to a wide range of substrates.关键词
喹喔啉骨架/乙腈/吡咯苯胺/酸催化/[5+1]环化Key words
quinoxaline skeleton/acetonitrile/pyrrolidine/acid catalysis/[5+1]cyclization分类
化学化工引用本文复制引用
万佳,李珍珍,刘珊珊..乙腈与吡咯苯胺构筑喹喔啉的[5+1]环化反应[J].广州化学,2024,49(2):52-56,5.
