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首页|期刊导航|武警医学|康复疗法在部队高脂血症患者中的应用及其对巨噬细胞肿瘤坏死因子-α、白细胞介素-6的影响

康复疗法在部队高脂血症患者中的应用及其对巨噬细胞肿瘤坏死因子-α、白细胞介素-6的影响OACSTPCD

Application of rehabilitation therapy in military patients with hyperlipidemia and its effect on macrophage tumor necrosis factor-α and interleukin-6

中文摘要英文摘要

目的 探讨康复疗法在部队高脂血症患者中的应用及其对巨噬细胞肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响.方法 选取2021 年5 月至2023 年1 月武警重庆总队医院门诊及体检中心的部队高脂血症患者124 例进行研究,依据不同的治疗方式分为对照组和研究组两组,各62 例.对照组常规干预,研究组在此基础上应用康复疗法,观察对比两组依从性及干预前后血脂水平[三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)]、炎性因子水平(IL-6、TNF-α)变化以及心理状态[抑郁自评量表(SDS)、焦虑自评量表(SAS)]、生活质量评分[生活质量综合评定问卷(GQOLI-74 评分)].结果 研究组情绪控制、按时用药、坚持运动、合理饮食依从性比对照组高(P<0.05);研究组干预后HDL-C比对照组高(P<0.05),TG、LDL-C、TC、IL-6、TNF-α水平均比对照组低(P<0.05);研究组干预后GQOLI-74评分比对照组高,SDS、SAS评分比对照组低(P<0.05).结论 部队高脂血症患者应用康复疗法不仅可以降低机体中的炎症因子和血脂水平,还可以改善患者负性心理状态,提高其依从性和生活质量,值得推广应用.

Objective To investigate the application of rehabilitation therapy in military patients with hyperlipidemia and its effect o on macrophage tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).Methods A total of 124 military hyperlipidemia patients from May 2021 to January 2023 in Chongqing Municipal Corps Hospital of Chinese People's Armed Police Force were divided into two groups according to different treatment methods,62 cases in each group.The control group received routine intervention,while the research group applied rehabilitation therapy on this basis.The compliance of the two groups and the changes of blood lipid levels(TG,LDL-C,TC,HDL-C),inflammatory factors(IL-6,TNF-α),mental state(SDS and SA)and quality of life score[GQOLI-74 score]before and after intervention were observed and compared.Results The compliance of the study group was higher than that of the control group(P<0.05).After intervention,HDL-C in the study group was higher than that in the control group(P<0.05),and TG,LDL-C,TC,IL-6 and TNF-α levels were lower than those in the control group(P<0.05).After intervention,GQOLI-74 scores in the study group were higher than those in the control group,and SDS and SAS scores were lower than those in the control group(P<0.05).Conclusions Rehabilitation therapy can not only reduce the levels of inflammatory factors and blood lipids,but also im-prove the negative psychological state of the patients,improve their compliance and quality of life,which is worthy of popularization and application.

郑黎黎;衡衍;蒲丹岚;廖涌;吴青蔓

400061,武警重庆总队医院,内分泌科400065,重庆邮电大学医院中医科401120,重庆市渝北区人民医院内分泌科400061,武警重庆总队医院,疼痛康复科

临床医学

康复疗法部队高脂血症巨噬细胞肿瘤坏死因子-α白介素-6生活质量依从性

rehabilitation therapyhyperlipidemia in the armymacrophage tumor necrosis factor-αinterleukin-6quality of lifecompliance

《武警医学》 2024 (004)

286-289,293 / 5

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