大黄糖络丸通过调控PI3K-Akt/NF-κB信号通路减轻糖尿病大鼠大血管炎症反应OA北大核心CSTPCD
Rhubarb sugar pills attenuate inflammatory response in large blood ves-sels of diabetic rats by regulating PI3K-Akt/NF-κB signaling pathway
目的:基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制.方法:15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄性ZDF(fa/fa)大鼠随机分为模型组,高、中、低剂量RSP组,以及二甲双胍组,每组15只.药物干预12周后,处死大鼠,分离血清,检测高密度脂蛋白胆固醇(HDL-C)、低密度脂…查看全部>>
AIM:To explore the mechanism of rhubarb sugar pills(RSP)in preventing and treating inflamma-tory response in large blood vessels of Zucker diabetic fatty(ZDF)rats based on phosphatidylinositol 3-kinase(PI3K)-pro-tein kinase B(PKB/Akt)/nuclear factor-κB(NF-κB)signaling pathway.METHODS:Fifteen male ZDF(fa/+)rats were used as the control group,and 75 male ZDF(fa/fa)rats fed with high-fat diet were randomly divided into model group,high-,medium-and low-dose RSP …查看全部>>
姚建莉;梁永林;任梦函;杨丽霞
甘肃中医药大学,甘肃 兰州 730000甘肃中医药大学,甘肃 兰州 730000甘肃中医药大学,甘肃 兰州 730000甘肃省中医药研究院,甘肃 兰州 730050
基础医学
大黄糖络丸糖尿病大血管病变ZDF大鼠炎症PI3K-Akt/NF-κB信号通路
rhubarb sugar pillsdiabetic macrovascular diseaseZDF ratsinflammationPI3K-Akt/NF-κB signaling pathway
《中国病理生理杂志》 2024 (4)
646-652,7
甘肃省高等学校产业支撑计划项目(No.2021CYZC-03)
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