"同一健康"理念应对抗菌药物耐药性全球危机OA

Antimicrobial resistance(AMR)has become a global public health crisis.Antibiotic resistance genes(ARGs)could be obtained by bacteria through gene mutations and horizontal gene transfer,being accelerated by long-term or irrational use of antibiotics,and distributed widely because of its cyclic transmission among humans-environment-animals,continuously producing multiple-resistant strains even pandrug-resistant strains,and posing a serious threat to global public health safety.In view of various and complex factors driving the spread of drug-resistant bacteria and ARGs,AMR should be thoroughly governed,and the"One Health"concept is internationally recognized as a strategic approach to address major and complex health issues.Following the discussion on the accessibility and transmission mechanism of ARGs and their main driving factors,its cyclic transmission among humans-environment-animals was analyzed in the paper,and countermeasures under the concept were proposed,aiming to provide a reference for AMR governance.