HIV感染者/AIDS患者衰弱状况及影响因素分析OA北大核心CSTPCD

Objective To investigate the frailty status and influencing factors in people living with human immuno-deficiency virus(HIV)infection/acquired immunodeficiency syndrome(AIDS)(PLWHA).Methods PLWHA aged ≥18 years in a hospital in Changsha City from June to August 2019 were selected as the study subjects.The basic condition and frailty of the subjects were evaluated by self-designed questionnaire and Tilburg frailty indicator,respectively.Results The incidence of frailty in PLWHA was 26.4％,logistic regression analysis showed that patients with infection years＞5 years had a 2.33 times higher risk of frailty compared with patients with infection years ≤5 years(95％CI:1.24-4.37,P=0.009).The risk of frailty in patients with a highest HIV load of≥100 000 copies/mL was 1.40 times higher than in patients with a highest HIV load of＜100 000 copies/mL(95％CI:1.05-1.85,P=0.022).The risk of frailty in patients with CD4+T lymphocyte count＜200 mm3 was 3.60 times higher than that in patients with CD4+T lymphocyte count ≥200 mm3(95％CI:1.96-6.62,P＜0.001).Conclusion PLWHA with longer duration of HIV infection,lower CD4+ T lymphocyte count and higher HIV load are more prone to develop frailty.