血红蛋白类氧载体在肿瘤治疗领域中的应用进展OACSTPCD

Most solid tumors suffer from inadequate blood perfusion and oxygenation,leading to a hypoxic microenviron-ment that accelerates tumor progression and adversely impacts prognosis.Thus,improving oxygenation in tumor tissues is crucial for enhancing the sensitivity and efficacy of tumor therapy.Hemoglobin-based oxygen carriers(HBOCs),as a type of oxygen-carrying nanoparticles,can not only carry and release oxygen but also reach the small blood vessels of obstructive mi-crocirculation to deliver oxygen for anoxic tissues and organs,which are difficult for normal red blood cells to pass through.Studies have demonstrated that the application of HBOCs as a potential nanoscale efficient oxygen carrier in tumor therapy can enhance tissue oxygenation and hold great promise for applications in tumor therapy.This review summarizes the impact of hypoxia in tumors and highlights the progress and potential mechanisms of using HBOCs in tumor radiotherapy,chemo-therapy,new kinetic therapy and immunotherapy.