瘢痕疙瘩表观遗传修饰的研究进展OA

Keloid is a benign fibroproliferative skin disease that occurs after skin injury due to excessive connective tissue growth.It is characterized by an increase in volume beyond the original injury site,and is often accompanied by itching and pain.The exact mechanisms underlying the development of Keloids are still not fully understood,but epigenetic modifications,inflammatory responses,and mechanical forces have all been implicated.Among these factors,epigenetic modifications play a key role in the pathogenesis of Keloids by influencing fibroblast behavior and gene expression.This review aims to summarize the role of epigenetic modifications in Keloids,providing further insights into the understanding of its pathogenesis and potential innovative therapies.