天然产物通过抑制PI3K信号通路抗肝纤维化的研究进展OA北大核心CSTPCD

Liver fibrosis is an intrinsic reaction of chronic liver injury,characterized by imbalance in synthesis,degradation and deposition of extracellular matrix(ECM),which may lead to damage of hepatocytes and destruction of normal liver structure.The abnormal activation of hepatic stellate cells(HSCs)is con-sidered to be the key factor driving liver fibrosis.In the process of liver injury,HSCs can be activated and transformed into myo-fibroblasts to produce excess ECM.Inflammation and oxidative stress play an important role in the activation of HSCs,while HSCs apoptosis is conducive to the regression of liver fibrosis.Inhibition of phosphatidylinositol-3-kinase(PI3K)signaling pathway can reduce inflammation and oxidative stress,induce ap-optosis of HSCs,and thus ameliorate liver fibrosis.Natural prod-ucts derived from plants,including flavonoids and terpenoids,can inhibit the occurrence and development of liver fibrosis by sup-pressing PI3K signaling pathway.Aiming to review the role of PI3 K signaling pathway in liver fibrosis,this article summarizes the evidence of anti-liver fibrosis effect of flavonoids and terpe-noids by inhibiting PI3 K signaling pathway in recent years,in or-der to provide reference for further development of drugs that can effectively prevent and treat liver fibrosis.