中国药理学通报2024，Vol.40Issue(4)：619-624,6.DOI:10.12360/CPB202208011
天然产物通过抑制PI3K信号通路抗肝纤维化的研究进展
Advances in natural products against liver fibrosis by inhibiting PI3K signaling pathway
摘要
Abstract
Liver fibrosis is an intrinsic reaction of chronic liver injury,characterized by imbalance in synthesis,degradation and deposition of extracellular matrix(ECM),which may lead to damage of hepatocytes and destruction of normal liver structure.The abnormal activation of hepatic stellate cells(HSCs)is con-sidered to be the key factor driving liver fibrosis.In the process of liver injury,HSCs can be activated and transformed into myo-fibroblasts to produce excess ECM.Inflammation and oxidative stress play an important role in the activation of HSCs,while HSCs apoptosis is conducive to the regression of liver fibrosis.Inhibition of phosphatidylinositol-3-kinase(PI3K)signaling pathway can reduce inflammation and oxidative stress,induce ap-optosis of HSCs,and thus ameliorate liver fibrosis.Natural prod-ucts derived from plants,including flavonoids and terpenoids,can inhibit the occurrence and development of liver fibrosis by sup-pressing PI3K signaling pathway.Aiming to review the role of PI3 K signaling pathway in liver fibrosis,this article summarizes the evidence of anti-liver fibrosis effect of flavonoids and terpe-noids by inhibiting PI3 K signaling pathway in recent years,in or-der to provide reference for further development of drugs that can effectively prevent and treat liver fibrosis.关键词
肝纤维化/肝星状细胞/PI3K信号通路/天然产物/黄酮类化合物/萜类化合物Key words
liver fibrosis/hepatic stellate cells/PI3K signaling pathway/natural products/flavonoids/terpenoids分类
医药卫生引用本文复制引用
朱武嫦,莫孝成,苏宏梅,韦锦斌..天然产物通过抑制PI3K信号通路抗肝纤维化的研究进展[J].中国药理学通报,2024,40(4):619-624,6.基金项目
国家自然科学基金资助项目(No 81960767) （No 81960767）
广西老年病防治药物基础研究重点实验室(桂卫科教发[2020]17号) （桂卫科教发[2020]17号）
