产气荚膜梭菌致病机制及其治疗性抗体研究进展OA北大核心CSTPCD

Clostridium perfringens(CP)is a common zoonotic pathogen that widely exists in nature and takes a heavy toll on human health and animal husbandry through its secreted exotoxins.The main pathogenic toxins of CP are α,β,ε and τ toxins,enterotoxins and necrotizing enteritis B-like toxins.The diseases caused by these toxins vary.Antibiotic therapy is currently the main method for the treat-ment of CP infection,but due to the growing drug resistance,it is increasingly difficult to control CP infection.In recent years,based on the rapid development of genetic engineering technologies,vaccines or antibodies against different exotoxins may become a new generation of immunotherapy for CP infec-tion.Studies have shown that the vaccines against CP α-toxin can prevent type A CP infection in mice.Anti-α-toxin single chain antibodies,bivalent single chain antibodies and nano-antibody can specifically bind to α-toxin,effectively neutralize the phospholipase C activity of α-toxin,and protect mice against lethal doses of α-toxin challenge.This article reviews the main pathogenic factors and mechanisms of CP and the research progress in genetic engineering antibody therapies so as to provide reference for the prevention and treatment of CP infection.