肝细胞癌过继细胞疗法研究进展OA

Hepatocellular carcinoma is a kind of disease that seriously threatens human survival.The mortality of hepatocellular carcinoma in China is the third in the world.Because there are no specific symptoms in the early stage of hepatocellular carcinoma,and the treatment scheme in the late stage has various disadvantages such as high recurrence rate,it is urgent to find effective new treatment methods.Adoptive cell therapy is a kind of cellular immunotherapy.In the diversified and complex immune microenvironment of the liver,adoptive cell therapy gradually plays an advantage in the treatment of hepatocellular carcinoma by combining tumor specific antigen or non-specific regulation of immune balance.In this review,we describe the morphological structures and signaling pathways of common biomarkers for targeted therapy of hepatocellular carcinoma,and discusses and summarizes the research methods and clinical effects of adoptive cell therapy for hepatocellular carcinoma in recent years,and looks forward to the next research direction.