中国医学前沿杂志（电子版）2024，Vol.16Issue(3)：34-39,6.DOI:10.12037/YXQY.2024.03-07
非肌少症老年人群血清酰基肉碱、溶血磷脂酰胆碱与握力的相关性研究
The correlation of acylcarnitine and Lys phosphatidylcholine with grip strength and gait speed in non-sarcopenia elderly population
摘要
Abstract
Objective Early identification and support of high-risk groups in clinically non-sarcopenia healthy elderly population has potential screening value.The correlation of serum acylcarnitine,Lys phosphatidylcholine metabolites with grip strength and gait speed in non-sarcopenic elderly population was studied.Methods A total of 182 non-sarcopenia elderly people who participated in physical examination in Beijing Hospital from June to December 2021 were selected as the research subjects by convenience sampling method.12 metabolites of acylcarnitine,Lys phosphatidylcholine,amino acids and other metabolites in serum were measured based on targeted liquid chromatography/tandem mass spectrometry,and the differences of metabolites concentration between the reduced grip strength group and the normal group were compared.In the subsequent analysis,step speed was added as a secondary indicator to study the correlation difference between metabolites and exercise assessment indicators such as grip strength,walk speed and(skeletal muscle mass index)SMI,and the ability of key metabolites to distinguish grip strength and walk speed decline in the elderly was evaluated by Logistics(receiver operating characteristic curve,ROC curve).Results The average grip strength of the subjects decreased by 20.33％(31.91±5.72)kg;The average walking speed was(1.01±0.31)m/s,decreased by 34.07％;The concentrations of C3,C14,LPC18:0 and glycine in decreased grip strength group were significantly higher than those in normal group(P＜0.05);Compared with the normal grip strength group,the grip strength of the subjects in the lower grip strength group decreased by 10.10 kg,and the pace decreased by 0.13 m/s(t=-2.363,P=0.019).C3 was increased by 0.020 μmol/L(t=2.222,P=0.028),LPC18∶0 was increased by 3.443 μmol/L(t=2.136,P=0.034),and glycine was increased by 0.33 μmol/L(t=2.489,P=0.017).No significant difference was found in the rest.Pearson correlation analysis showed that C3 and C14 showed opposite trends in different populations and the correlation was higher than C3,C14,LPC:18∶0,glycine combined with age and body mass index(BMI),the effect of grip strength decline in non-muscular elderly population was better than that of age and BMI alone.The area under curve(AUC)was 0.754(95％CI:0.658-0.849,P＜0.001)and 0.650(95％CI:0.545-0.754,P=0.011),respectively.The four metabolites combined with age and BMI were more effective.Conclusions Decline of grip strength and serum C3,C14 in non-sarcopenia aged population;LPC18∶0,glycine has a positive correlation with grip strength decline in non-sarcopenia elderly population,and it is expected to further explore its value in predicting grip strength decline in elderly people in cohort studies.关键词
肌少症/代谢组学/代谢物/握力/老年男性Key words
Sarcopenia/Metabolomics/Metabolites/Grip strength/Older men引用本文复制引用
于博洋,董娟,陈观洲,吕沛颖,周起,杨睿悦,孙亮,邱蕾..非肌少症老年人群血清酰基肉碱、溶血磷脂酰胆碱与握力的相关性研究[J].中国医学前沿杂志（电子版）,2024,16(3):34-39,6.基金项目
中央保健科研课题(2020YB07) （2020YB07）
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-050) （2021-I2M-1-050）
国家自然科学基金(91849132) Central Health Care Scientific Research Project(2020YB07),the CAMS Innovation Fund for Medical Sciences(2021-I2M-1-050),National Scientific Foundation of P.R.China(91849132) （91849132）
