国际口腔医学杂志2024，Vol.51Issue(3)：353-361,9.DOI:10.7518/gjkq.2024048
人工唾液的研究进展
Research progress on artificial saliva
摘要
Abstract
Saliva is a slightly acidic oral fluid,which is primarily composed of water.It also contains a small amount of inorganic ions and rich proteins,which results in its special rheological and biological properties,good biological func-tions,and important role in maintaining oral and systemic health.Xerostomia caused by decreased saliva flow or altered saliva composition can lead to clinically serious oral health imbalances,manifested by burning in the mouth;changes in taste;difficulty in speaking,chewing,and swallowing;and an increased risk of dental caries and periodontal disease,which seriously affect the quality of life of patients.The prevalence of xerostomia is approximately 20%,which increases to about 50%in the elderly population aged>75 years.With the increase in the aging population,xerostomia has caused a health burden that cannot be ignored.Artificial saliva is an oral care product developed to mimic the properties and func-tions of natural saliva,which is an important method of symptomatic treatment of xerostomia.Safe and effective artificial saliva has a positive effect and application potential in maintaining the oral health of the elderly.The development of arti-ficial saliva begins with a comprehensive understanding of the properties of natural saliva.This review systemati-cally depicted the composition and biological functions of natural saliva and described in detail the rheological behavior,tribological properties,biological characteris-tics,and clinical application performance of artificial saliva to promote the development of novel artificial saliva.关键词
唾液/人工唾液/流变学行为/摩擦学性质/生物学特性/临床应用Key words
saliva/artificial saliva/rheological behavior/tribological properties/biological characteristics/clini-cal application分类
医药卫生引用本文复制引用
甄亚斐,彭显,应斌武,张平,周学东,廖玍..人工唾液的研究进展[J].国际口腔医学杂志,2024,51(3):353-361,9.基金项目
National Natural Science Foundation of China(32371523,32071462) 国家自然科学基金(32371523,32071462) （32371523,32071462）
