人工唾液的研究进展OA北大核心CSTPCD

Saliva is a slightly acidic oral fluid,which is primarily composed of water.It also contains a small amount of inorganic ions and rich proteins,which results in its special rheological and biological properties,good biological func-tions,and important role in maintaining oral and systemic health.Xerostomia caused by decreased saliva flow or altered saliva composition can lead to clinically serious oral health imbalances,manifested by burning in the mouth;changes in taste;difficulty in speaking,chewing,and swallowing;and an increased risk of dental caries and periodontal disease,which seriously affect the quality of life of patients.The prevalence of xerostomia is approximately 20%,which increases to about 50%in the elderly population aged>75 years.With the increase in the aging population,xerostomia has caused a health burden that cannot be ignored.Artificial saliva is an oral care product developed to mimic the properties and func-tions of natural saliva,which is an important method of symptomatic treatment of xerostomia.Safe and effective artificial saliva has a positive effect and application potential in maintaining the oral health of the elderly.The development of arti-ficial saliva begins with a comprehensive understanding of the properties of natural saliva.This review systemati-cally depicted the composition and biological functions of natural saliva and described in detail the rheological behavior,tribological properties,biological characteris-tics,and clinical application performance of artificial saliva to promote the development of novel artificial saliva.