可吸收生物膜复合人工合成骨粉填充在牙种植患者中的应用效果OA
Application of Bio-Gide absorbable biofilm and artificial bone meal filling in patients taking dental implantation
目的 探讨可吸收生物膜复合人工合成骨粉填充在牙种植中的效果.方法 开展前瞻性随机对照试验.选取2020年1月至2022年4月在陕西中医药大学附属医院因牙列缺损就诊的98例单颗前牙缺失伴唇侧骨缺损患者作为研究对象,采用随机数字表法分为研究组和对照组,各49例.对照组男29例、女20例,年龄(40.95±8.03)岁,给予口腔修复膜复合人工合成骨粉填充;研究组男26例、女23例,年龄(41.37±7.86)岁,给予可吸收生物膜复合人工合成骨粉填充.对比两组患者种植体植入成功率(种植3个月、6个月、12个月)、种植体牙周健康情况(种植前、种植12个月)、种植体唇侧骨壁厚度(种植后即刻、种植12个月)、骨缺损再生情况(种植3个月)、种植体龈沟液因子(种植前、种植3个月)及并发症发生情况.采用t检验、x2检验.结果 两组患者种植3个月、6个月、12个月的种植成功率比较,差异均无统计学意义(均P＞0.05).种植前,两组患者牙周袋深度、附着丧失水平及牙龈沟出血指数比较,差异均无统计学意义(均P＞0.05);种植12个月,研究组牙龈沟出血指数、牙周袋深度、附着丧失水平均低于对照组[(1.01±0.16)比(1.13±0.19)、(2.19±0.36)mm 比(2.41±0.42)mm、(2.01±0.32)mm 比(2.23±0.38)mm],差异均有统计学意义(t=3.382、2.784、3.100,均P＜0.05).种植后即刻,两组患者1 mm、4 mm、7 mm、10 mm位点的唇侧骨厚度比较,差异均无统计学意义(均P＞0.05);种植12个月,研究组1 mm、4 mm、7 mm、10 mm位点的唇侧骨厚度均高于对照组[(2.21±0.36)mm比(2.03± 0.34)mm、(2.32±0.41)mm 比(2.07±0.38)mm、(2.39±0.41)mm 比(2.13±0.38)mm、(2.62±0.41)mm 比(2.31± 0.45)mm],差异均有统计学意义(t=2.545、3.130、3.256、3.565,均P＜0.05).研究组种植3个月的植骨高度、成骨高度均高于对照组[(2.71±0.43)mm 比(2.42±0.39)mm、(2.62±0.41)mm 比(2.29±0.37)mm],差异均有统计学意义(t=3.497、4.183,均P＜0.05).种植前,两组患者血管内皮生长因子(VEGF)、骨形成蛋白-2(BMP-2)水平比较,差异均无统计学意义(均P＞0.05);种植3个月,研究组VEGF、BMP-2水平均高于对照组[(46.58±7.12)mg/L 比(39.56±6.28)mg/L、(486.57±62.18)ng/L 比(429.84±59.67)ng/L],差异均有统计学意义(t=5.176、4.608,均P＜0.05).两组患者并发症发生率比较[10.20％(5/49)比8.16％(4/49)],差异无统计学意义(x2=0.122,P=0.727).结论 可吸收生物膜复合人工合成骨粉填充在牙种植中可改善种植体牙周健康情况,减少患者术后骨量丢失,促进骨缺损再生.
Objective To investigate the effect of Bio-Gide absorbable biofilm combined with synthetic bone meal filling for patients taking dental implantation.Methods Ninety-eight patients with single anterior tooth loss and labial bone defect treated at Hospital Affiliated to Shaanxi University of Traditional Chinese Medicine from January 2020 to April 2022 were selected and divided into a study group and a control group by the random number table method,with 49 cases in each group.The control group included 29 males and 20 females who were(40.95±8.03)years old.The study group included 26 males and 23 females who were(41.37± 7.86)years old.The control group took oral repair membrane and synthetic bone meal filling.The study group took Bio-Gide absorbable biofilm combined with synthetic bone meal filling.The implant success rates 3,6,and 12 months after the implantation,periodontal health and labial bone wall thicknesses before and 12 months after the implantation,bone defect regeneration 3 months after the implantation,levels of gingival crevicular fluid factors before and 3 months after the implantation,and postoperative complications 12 months after the implantation were compared between the two groups.t and x2 tests were applied.Results There were no statistical differences between the two groups in the implant success rates 3,6 and 12 months after the implantation and periodontal pocket depth,attachment loss,and gingival bleeding index before the implantation(all P＞0.05).Twelve months after the implantation,the gingival bleeding index,periodontal pocket depth,and attachment loss in the study group were lower than those in the control group[(1.01± 0.16)vs.(1.13±0.19),(2.19±0.36)mm vs.(2.41±0.42)mm,and(2.01±0.32)mm vs.(2.23±0.38)mm],with statistical differences(all P＜0.05).There were no statistical differences in the labial bone thicknesses at the 1,4,7,and 10 mm sites between the two groups right after the implantation(all P＞0.05);12 months after the implantation,the labial bone thicknesses at the 1,4,7,and 10 mm sites in the study group were higher than those in the control group[(2.21±0.36)mm vs.(2.03±0.34)mm,(2.32±0.41)mm vs.(2.07±0.38)mm,(2.39±0.41)mm vs.(2.13±0.38)mm,and(2.62±0.41)mm vs.(2.31±0.45)mm],with statistical differences(t=2.545,3.130,3.256,and 3.565;all P＜0.05).Three months after the implantation,the bone graft height and osteogenic height of the study group were higher than those of the control group[(2.71±0.43)mm vs.(2.42±0.39)mm,(2.62±0.41)mm vs.(2.29±0.37)mm],with statistical differences(t=3.497 and 4.183;both P＜0.05).There were no statistical differences in the levels of vascular endothelial growth factor(VEGF)and bone morphogenetic protein-2(BMP-2)between the two groups before the implantation(both P＞0.05).Three months after the implantation,the levels of VEGF and BMP-2 in the study group were higher than those in the control group[(46.58±7.12)mg/L vs.(39.56±6.28)mg/L and(486.57±62.18)ng/L vs.(429.84±59.67)ng/L],with statistical differences(t=5.176 and 4.608;both P＜0.05).There was no statistical difference in the incidence of total complications between the two groups[8.16％(4/49)vs.10.20％(5/49);x2=0.122;P=0.727].Conclusion Bio-Gide absorbable biofilm combined with synthetic bone meal for patients taking dental implantation can improve their periodontal health,reduce their bone loss after surgery,and promote the regeneration of bone defects.
杨丹;雷明辉;付敬敏
陕西中医药大学附属医院口腔科,咸阳 712000咸阳市第一人民医院口腔科,咸阳 712000
牙列缺损可吸收生物膜人工合成骨粉牙种植
Dentition defectBio-Gide absorbable biofilmSynthetic bone mealDental implantation
《国际医药卫生导报》 2024 (007)
1125-1130 / 6
陕西省科技发展计划(2021QJ-412) Project of Plan of Science and Technology Development in Shaanxi(2021QJ-412)
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