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Wnt信号通路在急性心肌梗死中的研究进展OA

Research progress of Wnt signaling pathway in acute myocardial infarction

中文摘要英文摘要

Wnt信号通路是由配体蛋白Wnt和膜蛋白受体结合激发下游信号分子产生级联反应的信号转导途径.Wnt信号通路是调控细胞生长、增殖、分化的关键途径.急性心肌梗死(AMI)后心肌细胞再生能力有限,成纤维细胞大量增殖,形成瘢痕组织,心肌重构导致左心室功能下降.因此,促进心肌再生、减少瘢痕面积对于心肌梗死后心脏功能的改善具有重要意义.无论是在正常的心肌细胞还是心血管疾病形成和发展过程中,均有Wnt信号通路的参与.研究Wnt信号通路在AMI中的作用可以为AMI治疗提供新的依据与思路.本文对Wnt信号通路在AMI发展过程中的相关研究进展进行综述.

Wnt signaling pathway is a signal transduction pathway by which ligand protein Wnt binds to membrane protein receptors to stimulate downstream signaling molecules to produce cascade reactions.Wnt signaling pathway is a key pathway to regulate cell growth,proliferation,and differentiation.After acute myocardial infarction(AMI),the regeneration capacity of cardiomyocytes is limited,the fibroblasts multiply greatly,and the scar tissue is formed.Myocardial remodeling leads to decreased left ventricular function.Therefore,promoting myocardial regeneration and reducing scar area are of great significance for improving cardiac function after myocardial infarction.Wnt signaling pathway is involved both in normal cardiomyocytes and in the formation and development of cardiovascular diseases.The study on the role of Wnt signaling pathway in AMI can provide a new basis for the treatment of AMI.In this paper,we review the research progress of Wnt signaling pathway in the development of AMI.

杨寿娟;张海涛;崔明丽;王建;李洋;程艳丽

滨州医学院附属医院心内科,滨州 256603滨州医学院附属医院神经外科,滨州 256603

急性心肌梗死Wnt信号通路心肌细胞干细胞移植进展

Acute myocardial infarctionWnt signaling pathwayCardiomyocytesStem cell transplantationProgress

《国际医药卫生导报》 2024 (008)

1291-1296 / 6

山东省自然科学基金青年项目(ZR2020QH104) Shandong Province Natural Science Foundation Youth Project(ZR2020QH104)

10.3760/cma.j.issn.1007-1245.2024.08.013

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