心肌纤维化与AMPK-mTOR-ULK1信号通路研究进展OA

Myocardial fibrosis is an important pathological change in the occurrence and development of many cardiovascular diseases,and it is also the pathological basis of heart pump failure and adverse cardiovascular events,which is mainly manifested by excessive deposition of extracellular matrix(ECM)and continuous proliferation of cardiac fibroblasts(CFs).Adenylate activated protein kinase(AMPK)signaling pathway is the main system to mediate phosphorylation.AMPK activates autophagy,inhibits mammalian target of rapamycin(mTOR),and phosphorylates Unc-51-like autophagy activated kinase 1(ULK1).AMPK signaling pathway plays an important role in the occurrence and development of myocardial fibrosis.This paper analyzes the role of AMPK-mTOR-ULK1 signaling pathway in myocardial fibrosis,hoping to provide guidance for the treatment of myocardial fibrosis.