国际医药卫生导报2024，Vol.30Issue(8)：1316-1320,5.DOI:10.3760/cma.j.issn.1007-1245.2024.08.018
m6A及m5C甲基化修饰通过促进细胞增殖与转移影响癌症的发生和发展
m6A and m5C methylation modification affects the initiation and development of cancers by regulating cellular proliferation and metastasis
摘要
Abstract
So far,more than 170 chemical modifications have been found in RNA.RNA methylation modification is an important post-transcriptional regulation process.N6-methyladenosine(m6A)and 5-methylcytosine(m5C)are ubiquitous in eukaryotes and prokaryotes.Additionally,more and more attention has been paid to the exploration of RNA methylation within regulating gene expression and regulating the cellular biological activity in the tumor cells.Furthermore,some known cell signal pathways involved in cellular proliferation and metastasis are closely related to cancers immunity and metabolic regulation,and these signal pathways play an important role in regulating organ size,tissue regeneration,and stem cell self-renewal,which ultimately affects the initiation and development of tumors.In this review,we discuss that the m6A and m5C methylation regulate the occurrence and development of cancers through some popular pathways in human cancers,which provides a new theoretical basis for understanding and seeking new therapeutic disease approaches.关键词
RNA甲基化修饰/信号通路/N6-甲基腺苷/5-甲基胞嘧啶/癌症发生和发展/进展Key words
RNA methylation modification/Signal pathways/m6A/m5C/Initiation and development of cancers/Progress引用本文复制引用
邵爽,郭纪伟,孟玮..m6A及m5C甲基化修饰通过促进细胞增殖与转移影响癌症的发生和发展[J].国际医药卫生导报,2024,30(8):1316-1320,5.基金项目
山东省高等学校"青创科技计划"(2020KJK002) （2020KJK002）
"齐鲁卫生与健康杰出青年人才"项目 "Youth Innovation Science and Technology Plan"of Colleges and Universities in Shandong Province(2020KJK002) （2020KJK002）
"Qilu Outstanding Young Talents in Health" （）
