m6A及m5C甲基化修饰通过促进细胞增殖与转移影响癌症的发生和发展OA

So far,more than 170 chemical modifications have been found in RNA.RNA methylation modification is an important post-transcriptional regulation process.N6-methyladenosine(m6A)and 5-methylcytosine(m5C)are ubiquitous in eukaryotes and prokaryotes.Additionally,more and more attention has been paid to the exploration of RNA methylation within regulating gene expression and regulating the cellular biological activity in the tumor cells.Furthermore,some known cell signal pathways involved in cellular proliferation and metastasis are closely related to cancers immunity and metabolic regulation,and these signal pathways play an important role in regulating organ size,tissue regeneration,and stem cell self-renewal,which ultimately affects the initiation and development of tumors.In this review,we discuss that the m6A and m5C methylation regulate the occurrence and development of cancers through some popular pathways in human cancers,which provides a new theoretical basis for understanding and seeking new therapeutic disease approaches.