基于GEPIA数据库分析胃癌和正常组织的差异表达基因及对预后影响OA北大核心CSTPCD
Analysis of differential genes in gastric cancer and normal tissues and their impact on survival and prognosis based on GEPIA database
目的:基于GEPIA数据库分析正常胃组织与胃癌组织差异表达基因及其对胃癌患者生存预后的影响.方法:利用GEPIA数据库来获取胃癌组织和正常组织的差异基因,然后在GEPIA平台上确认筛选出的基因并对其进行生存预后分析.结果:通过GEPIA数据库分析得到差异表达基因4 644个,其中排在前 10 位的基因分别为:PRR11、CLDN7、TPX2、GNL3L、SKA3、ADHFE1、MTDH、CEP55、KIF11、KIF20B.其中ADHFE1基因与胃癌患者生存预后呈负相关,CEP55基因与胃癌患者生存预后呈正相关.结论:胃癌组织与正常组织之间存在差异表达基因,其中ADHFE1基因和CEP55基因对胃癌患者的生存预后推断具有重要价值.
Objective:To analyze the differentially expressed genes between normal gastric tissues and gastric cancer and the influence of differentially expressed genes on the survival and prognosis of patients with gastric cancer based on GEPIA data-base.Methods:The top differential genes between normal and gastric cancer tissues were obtained from GEPIA database,and the screened genes were verified on GEPIA website for prognostic analysis.Results:A total of 4 644 differentially expressed genes were identified in GEPIA database.The top 10 genes were PRR11,CLDN7,TPX2,GNL3L,SKA3,ADHFE1,MTDH,CEP55,KIF11,and KIF20B.ADHFE1 gene was negatively correlated with the survival and prognosis of gastric cancer pa-tients,while CEP55 gene was positively correlated with the survival and prognosis of gastric cancer patients.Conclusion:There are differential genes between gastric cancer and normal tissues,and ADHFE1 and CEP55 genes may play an important role in the survival and prognosis of gastric cancer.
张紫涵;陈明明;刘君;桑圣刚;张荣光
海南医学院公共卫生与全健康国际学院,海南 海口 571199海南医学院基础医学与生命科学学院,海南 海口 571199海南医学院第一附属医院检验科,海南 海口 570102海南医学院公共卫生与全健康国际学院,海南 海口 571199||海南医学院第一附属医院检验科,海南 海口 570102
临床医学
GEPIA数据库胃癌生存预后
GEPIA databaseGastric cancerSurvival prognosis
《海南医学院学报》 2024 (008)
591-596 / 6
This study was supported by National Natural Science Foundation of China(82160634) 国家自然科学基金资助项目(82160634)
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