海南医学院学报2024，Vol.30Issue(8)：591-596,6.DOI:10.13210/j.cnki.jhmu.20231220.001
基于GEPIA数据库分析胃癌和正常组织的差异表达基因及对预后影响
Analysis of differential genes in gastric cancer and normal tissues and their impact on survival and prognosis based on GEPIA database
摘要
Abstract
Objective:To analyze the differentially expressed genes between normal gastric tissues and gastric cancer and the influence of differentially expressed genes on the survival and prognosis of patients with gastric cancer based on GEPIA data-base.Methods:The top differential genes between normal and gastric cancer tissues were obtained from GEPIA database,and the screened genes were verified on GEPIA website for prognostic analysis.Results:A total of 4 644 differentially expressed genes were identified in GEPIA database.The top 10 genes were PRR11,CLDN7,TPX2,GNL3L,SKA3,ADHFE1,MTDH,CEP55,KIF11,and KIF20B.ADHFE1 gene was negatively correlated with the survival and prognosis of gastric cancer pa-tients,while CEP55 gene was positively correlated with the survival and prognosis of gastric cancer patients.Conclusion:There are differential genes between gastric cancer and normal tissues,and ADHFE1 and CEP55 genes may play an important role in the survival and prognosis of gastric cancer.关键词
GEPIA数据库/胃癌/生存预后Key words
GEPIA database/Gastric cancer/Survival prognosis分类
医药卫生引用本文复制引用
张紫涵,陈明明,刘君,桑圣刚,张荣光..基于GEPIA数据库分析胃癌和正常组织的差异表达基因及对预后影响[J].海南医学院学报,2024,30(8):591-596,6.基金项目
This study was supported by National Natural Science Foundation of China(82160634) 国家自然科学基金资助项目(82160634) （82160634）
