单细胞测序技术在慢性阻塞性肺疾病研究中的应用进展OA北大核心CSTPCD

Chronic obstructive pulmonary disease(COPD)is a polygenic disease caused by the interaction of genes and envi-ronment,with persistent airflow limitation as the main clinical feature.There is a lack of reliable methods for early diagnosis of COPD,which prevents timely and effective intervention in patients with early COPD and fails to stop the progression of the dis-ease,resulting in its high morbidity,prevalence and mortality and causing a serious disease burden.With the launch of the Human Cell Atlas Project and the development of sequencing technology,the application prospect of single cell sequencing(SCS)is wide-ly looked forward to,which is a new technology for sequencing and analyzing genome,transcriptome and proteome at the level of single cell,enough to reveal the gene structure and expression of single cell,discover the heterogeneity between cells and rare cells,etc.It provides a new research technique for the in-depth study of the pathogenesis of chronic obstructive pulmonary disease,the discovery of early diagnosis methods and new treatment methods.In this paper,we review the progress of single-cell sequenc-ing technology and its application in the study of COPD.