海南医学院学报2024，Vol.30Issue(8)：623-633,11.DOI:10.13210/j.cnki.jhmu.20230901.005
黎药天然产物调控AMPK抗MAFLD作用的研究进展
Research progress on natural products of Li medicine in improving MAFLD by the AMPK pathway
摘要
Abstract
Metabolism-associated fatty liver disease(MAFLD)is the hepatic manifestation of metabolic syndrome,with a global incidence up to 25%in adults,and has replaced viral hepatitis as the first chronic liver disease in China.Adenosine mono-phosphate-activated protein kinase(AMPK)is an important key enzyme in the regulation of glycolipid metabolism in vivo.The ac-tivation of AMPK is thought to have the ability to improve glucose and lipid metabolism disorder,alleviate oxidative stress,pos-sess anti-inflammatory,regulate autophagy affects,and protect the mitochondria to play a therapeutic role in the treatment of MAFLD.As an important treasure trove of medicinal resources in traditional Chinese medicine,natural products of Li medicine have been widely found to activate AMPK and exhibit excellent effects in improving MAFLD.Therefore,this review is planned to summarize the association mechanisms between MAFLD improvement and AMPK activation of Li medicine and its natural prod-ucts,to provide theoretical references for the exploration and development of Li medicine and its natural products.There by pro-moting modernization industry development of Li medicine.关键词
黎药/黎药天然产物/AMPK/MAFLDKey words
Li medicine/Natural products of Li medicine/AMPK/MAFLD分类
医药卫生引用本文复制引用
陈咪咪,卢文蕾,于晏苏,周媛媛,张小坡,张勇,张寿文..黎药天然产物调控AMPK抗MAFLD作用的研究进展[J].海南医学院学报,2024,30(8):623-633,11.基金项目
This study was supported by National Natural Science Foundation of China(82204476) （82204476）
Innovation and Entrepreneurship Training Program for College Students(202211810022) 国家自然科学基金资助项目(82204476) （202211810022）
大学生创新创业训练计划项目(202211810022) （202211810022）
