CXCL趋化因子在头颈部鳞状细胞癌中的表达及临床意义OA北大核心CSTPCD

Objective This study investigated the expression levels of CXCL chemokines in head and neck cancer and their value as diagnostic and prognostic markers.Methods Public databases were used in the analysis of various abnor-mally expressed CXCL factors in head and neck cancer and their correlation with the poor prognoses of patients with head and neck cancer,and the correlation between CXCL family and immune factor infiltration was determined.Results Compared with normal tissues,CXCL is differentially expressed in head and neck squamous cell carcinoma(HNSCC)tis-sues and pathological stages,and it is closely related to long overall survival(OS)and immune cell infiltration in patients with HNSCC.CXCL chemokine gene function in HNSCC is mainly concentrated in chemokine activity.The KEGG path-way is mainly concentrated in cytokine-cytokine receptor interaction,and the CXCL family has a certain mutation rate in HNSCC.Conclusion Tumor bioinformatics analysis showed that the expression levels of the CXCL family in HNSCC tissues are different from those in normal tissues and correlated with immune cell infiltration and tumor prog-nosis,showing potential as prognostic markers for HNSCC and gene therapy targets.