食品科学2024，Vol.45Issue(9)：36-43,8.DOI:10.7506/spkx1002-6630-20230627-211
壳聚糖-透明质酸钠-益生菌水凝胶的制备、表征及胃肠道缓释作用
Preparation and Characterization of Chitosan-Sodium Hyaluronate-Probiotic Hydrogels and Its Sustained-Release Performance in Simulated Gastrointestinal Tract Conditions
摘要
Abstract
A physically cross-linked hydrogel was constructed by electrostatic interaction between chitosan(CS)and sodium hyaluronate(SH),and its texture properties,microstructure and functional properties were characterized.Meanwhile,the influence of loading with one of the probiotics Lactobacillus rhamnosus and Pediococcus acidilactici on texture characteristics and microstructure of the hydrogel was evaluated,the loading performance was analyzed,and the release mechanism of probiotic-loaded hydrogels in simulated gastroenteric fluid was explored.The results showed that CS-SH hydrogel,which was formed through electrostatic crosslinking,had good texture properties and bacteria-loading properties,and the loading capacity of 0.2 g(dry mass)of hydrogels for L.rhamnosus and P.acidilactici was 1.15 × 109 and 1.25 × 109 CFU,respectively.The probiotic-loaded hydrogel was continuously released in simulated intestinal fluid,and its release mechanism was through surface erosion.The maximum viable counts of L.rhamnosus and P.acidilactici in simulated intestinal fluid were 6.30 and 6.12(1g(CFU/mL)),respectively.To sum up,CS-SH hydrogel is a potential probiotic delivery carrier that can be continuously released in simulated intestinal fluid.This study provides theoretical guidance and a research basis for the application and mechanism of action of physically crosslinked hydrogels in the field of probiotic loading.关键词
物理交联水凝胶/壳聚糖/透明质酸钠/载菌性能/胃肠消化模拟Key words
physically cross-linked hydrogels/chitosan/sodium hyaluronate/bacteria-loading performance/simulated gastrointestinal digestion分类
轻工业引用本文复制引用
厉佳怡,王红磊,李娅婕,郭婷婷,倪乙丹,周泉城,盛桂华..壳聚糖-透明质酸钠-益生菌水凝胶的制备、表征及胃肠道缓释作用[J].食品科学,2024,45(9):36-43,8.基金项目
山东省重点研发计划项目(2019GNC106084) （2019GNC106084）
