中国食品添加剂2024，Vol.35Issue(4)：192-200,9.DOI:10.19804/j.issn1006-2513.2024.4.023
云南腾冲牛至精油成分及其抗炎和抗衰老活性特征
Components analysis of Origanum vulgare L.essential oil from Tengchong,Yunnan and its anti-inflammatory and anti-aging activities
摘要
Abstract
Components of Origanum vulgare L.essential oil(OvEo)from the Tengchong,Yunnan was analyzed using gas chromatography-mass spectrometry,and its anti-inflammatory and anti-aging effects in vitro and in vivo were evaluated.The analysis identified 15 chemical components in OvEo,with carvacrol(52.68%),eucalyptol(11.4%),and terpinen-4-ol(4.97%)as the major components.At a concentration of 100 μg/mL,OvEo significantly suppressed the secretion of TNF-α,IL-6,and NO in RAW264.7 cells,while also reduced the migration of neutrophils in zebrafish induced by CuSO4,indicating its notable anti-inflammatory activity.Furthermore,OvEo exhibited a strong anti-aging effect by effectively scavenging reactive oxygen species,inhibiting β-galactosidase secretion,and suppressing collagenase and elastase activity with half maximal inhibitory concentrations(IC50)of 6.72 mg/mL and 30.7 mg/mL,respectively.OvEo from Tengchong,Yunnan,exhibited excellent anti-inflammatory and anti-aging effects,which demonstrates its excellent potential applications as a natural anti-inflammatory and anti-aging agent.关键词
云南腾冲/牛至精油/成分分析/抗炎/抗衰老Key words
Tengchong,Yunnan/Origanum vulgare L.essential oil/components analysis/anti-inflammatory/anti-aging分类
轻工纺织引用本文复制引用
梅早菊,吴信浪,曲丽萍..云南腾冲牛至精油成分及其抗炎和抗衰老活性特征[J].中国食品添加剂,2024,35(4):192-200,9.基金项目
云南特色植物提取实验室自主研究项目基金(2022YKZY001). （2022YKZY001）
